Interrelationship of minerals in pregnant women and their neonates

Serum ionized calcium, total calcium, management, inorganic phosphorus, total protein, albumin and alkaline phosphates were determined in 30 non pregnant [controls] and 30 pregnant women delivering full term, full term low birth weight and preterm neonates [n=30 each]. Comparison of control non-pregnant with pregnant groups show significant differences. A statistically significant difference was observed in serum mineral levels of term neonates when compared with preterm neonates

Study of serum magnesium in ischaemic heart disease

To study the serum magnesium level in various clinical entities of ischaemic heart disease. Design: Comparative study of serum magnesium in 95 patients of ischaemic heart disease with 20 age matched control subjects. Settings: Cardiology unit, Mayo Hospital, Lahore. Subjects: Ninety five male patients of myocardial infarction. Intermediate coronary syndrome and angina admitted in cardiology unit. Main outcome measures: Predispoing risk factor. Serum mangnesium was found to be significantly low [P<0.01] in patients of myocardial infarction after first attack as compared with normal controls [0.86 +/- 0.019 vs 0.946 +/- 0.019]. The mean values were also found to be low in other categories of the disease but the difference was statistically non significant. Low serum magnesium was found in patients of ischaemic heart disease. Supplementation should be given after estimation of serum magnesium. The drugs like diuretics, digitalis and potassium should be given after estimation of serum magnesium. The drugs like diuretics, digitalis and potassium should be used with great care

Study of risk factors in coronary heart disease

Study of risk factors was conducted in 92 patients suffering from acute attack of myocardial infarction, admitted to Coronary Care Unit, Mayo Hospital, Lahore. The diagnosis of infarction was based on clinical history, ECG findings, enzyme and isoenzyme studies. Among the major risk factors smoking was at the top and 67per cent of patients were smokers. Hypercholestrolaemia was found in 30 per cent, Hypertension in 16 per cent and Diabetes mellitus in 14 per cent of patients. The role of minor risk factors like age, sex, occupation, genetics and stress was also studied. The age range was 20-89 years

Serum uric acid ischemic heart disease

Serum Uric Acid was done in 150 male patients suffering from ischaemic heart disease [angina pectoris 67 and myocardial infarction 83] and 30 controls. Serum Uric Acid was significantly raised [P<0.001] in patients as compared to controls. It is suggested that in assessing the susceptibility of a person to ischaemic heart disease [IHD] serum uric acid Values should be considered as a predictor amongst other risk factors

Study of serum isoenzymes of creatine phosphokinase and lactate dehydrogenase in myocardial infarction

Total serum enzyme levels of creatine phosphokinase and lactate dehydrogenase as well as their isoenzymes CKMB and HBDH [LDH]1 were measured in 92 patients [74 males and 18 females] admitted consecutively to coronary care unit. The isoenzymes were determined on first day of admission while the total enzymes were measured on first three consecutive days of admission. The patients were divided into two main groups, which were further classified in four subgroups according to age, E.C.G changes, location of infarct and the frequency of attack and its repetition The combined use of CPK and LDH isoenzymes provided the best specificity for the diagnosis of acute myocardial infarction, and a good correlation with clinical and electrocardiographic findings