ABSTRACT
Hyperglycemia, a well recognized pathogenic factor of long-term complications in diabetes mellitus, not only generates more reactive oxygen species but also attenuates antioxidative mechanisms. Therefore, oxidative stress has been considered to be a common pathogenetic factor of the diabetic complications including nephropathy. Tumor necrosis factor-alpha [TNF-alpha] has been implicated as a link between insulin resistance, diabetes and endothelial dysfunction. The present study was undertaken to investigate whether treatment of streptozotocin-induced diabetic rats with a combination therapy of angiotensin converting enzyme inhibitor [ramipril] and vitamin E reduce the possible hazards of oxidative damage induced by reactive oxygen species. Forty male adult albino rats divided into 5 groups each included 8 rats and arranged as control group, streptozotocin-induced diabetic group [60 mg/kg b.wt.i.p.], ramipril + diabetic group, vitamin E + diabetic group and ramipril + vitamin E + diabetic group. Ramipril was given in a dose of 10