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Rev. bras. cir. cardiovasc ; 27(3): 429-435, jul.-set. 2012. ilus, tab
Article in Portuguese | LILACS | ID: lil-660815

ABSTRACT

INTRODUÇÃO: As complicações neurológicas são temidas no pós-operatório das cirurgias cardíacas, sendo importante causa de óbito e de gastos hospitalares. Sua predição ainda é incerta. OBJETIVO: Avaliar a aplicabilidade de um escore pré-operatório como preditor de disfunção neurológica no pós-operatório de revascularização miocárdica (RM) com circulação extracorpórea (CEC). MÉTODOS: Estudo prospectivo que avaliou 77 pacientes submetidos à RM no período de fevereiro a outubro de 2011. Utilizando-se o escore CABDEAL (creatinine, age, body mass index, diabetes, emergency surgery, abnormality on ECG, lung disease), os pacientes foram agrupados em alto (CABDEAL > 4) e baixo risco (CABDEAL<4). Para os desfechos encefalopatia e acidente vascular encefálico (AVE), foram comparados os valores preditivos do escore e das variáveis intra e pós-operatórias (tempos de pinçamento aórtico, CEC e ventilação mecânica). O teste exato de Fischer foi usado na análise estatística. A análise da curva ROC foi utilizada para avaliar a acurácia do modelo para os desfechos neurológicos. Adotou-se o nível de significância P<0,05. RESULTADOS: A taxa de mortalidade foi de 2,6% (n=2). Ocorreram dois episódios de AVE (2,6%) e 12 (15,5%) de encefalopatia. O desfecho encefalopatia associou-se significativamente com CABDEAL de alto risco (P=0,0009), tempo de ventilação mecânica (P=0,014), tempo de CEC (P=0,02), e tempo de pinçamento aórtico (P=0,006); este último associou-se também com AVE (P=0,03) e óbito (P=0,006). O escore CABDEAL apresentou maior área sob a curva ROC do que as demais variáveis para o desfecho encefalopatia. CONCLUSÃO: Na amostra estudada, o escore CABDEAL foi melhor preditor de encefalopatia no pós-operatório de RM quando comparado às variáveis intraoperatórias analisadas.


INTRODUCTION: Neurological dysfunction is a feared postoperative morbidity of cardiac surgery, an important cause of death and increased spending in hospitals. Its prediction, however, is still uncertain. OBJECTIVE: To assess the applicability of a preoperative score as a predictor of neurological dysfunction after coronary artery bypass grafting (CABG) under cardiopulmonary bypass (CPB). METHODS: Prospective study that evaluated 77 patients who underwent CABG from February to October 2011. Using the score CABDEAL (creatinine, age, body mass index, diabetes, emergency surgery, abnormality on ECG, lung disease), patients were grouped into high (CABDEAL > 4) and low risk (CABDEAL<4). The predictive value of the score was compared with intraoperative and postoperative variables (aortic clamping time, CPB and ventilation time) as predictors of encephalopathy and stroke. Data were analyzed with descriptive statistics and compared with the Fisher exact test. ROC curve analysis was performed to evaluate the accuracy of the model for the neurological outcomes. It was considered the significant value P<0.05. RESULTS: The mortality rate was 2.6% (n=2). There were 2 episodes of stroke (2.6%) and 12 (15.5%) of encephalopathy. High risk CABDEAL (P=0.0009), ventilation time (P=0.014), CPB time (P=0.02) and aortic clamping time (P=0.006) were significantly associated with encephalopathy. The aortic clamping time was also associated with stroke (P=0.03) and death (P=0.006). CABDEAL score showed the largest area under the ROC curve rather than others variables. CONCLUSION: In this study, the CABDEAL score stood out as the best predictor of encephalopathy after CABG when compared to the others intraoperative variables.


Subject(s)
Adult , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Brain Diseases/etiology , Coronary Artery Bypass/adverse effects , Aorta/surgery , Brain Diseases/mortality , Constriction , Coronary Artery Bypass/mortality , Epidemiologic Methods , Intraoperative Period , Length of Stay , Postoperative Period , Reference Values , Risk Assessment , Risk Factors , Stroke/etiology , Stroke/mortality
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