ABSTRACT
We report a rare case of extranodal histiocytic sarcoma with multifocal gastrointestinal tract involvement, which has not been documented in the literature so far. A diagnosis of interdigitating dendritic cell/ histiocytic sarcoma was made on the preoperative gastric biopsy. Computed tomography scan revealed multifocal, circumferential gastrointestinal wall thickening involving the stomach and jejunal loops. Patient underwent distal gastrectomy with extended D1 dissection and proximal jejunal resection with gastrojejunostomy. Immunohistochemistry profile of both the gastric and jejunal tumors was similar to the preoperative gastric biopsy. The histiocytic origin of the tumor was confirmed by positive reaction of the tumor cells for CD 163. She received four cycles of CHOP chemotherapy, and is free of disease three years, following surgery.
Subject(s)
Adult , Antigens, CD/analysis , Antigens, Differentiation, Myelomonocytic/analysis , Biopsy , Female , Gastrectomy , Gastric Bypass , Gastrointestinal Neoplasms/diagnosis , Gastrointestinal Neoplasms/pathology , Gastrointestinal Neoplasms/surgery , Histiocytic Sarcoma/diagnosis , Histiocytic Sarcoma/pathology , Histiocytic Sarcoma/surgery , Histocytochemistry , Humans , Immunohistochemistry , Jejunum/pathology , Microscopy , Receptors, Cell Surface/analysis , Stomach/pathology , Tomography, X-Ray ComputedABSTRACT
No abstract available.
Subject(s)
Female , Cervix Uteri , Leukemia, Lymphocytic, Chronic, B-Cell , VulvaABSTRACT
Bendamustine has been recently approved for the treatment of low-grade lymphoproliferative disorders. There is little data on the effectiveness or toxicity of this drug outside the trial setting. This is the first report on the use of bendamustine from the Indian subcontinent. Retrospective descriptive analysis of response and side effects of bendamustine in eight patients with chronic lymphocytic leukemia and eight patients with follicular lymphoma. Data was collated from a review of case records. We examined any association between side effects and clinical parameters. The median age of patients was 52 years and three-quarters had received prior treatment with alkylators or fludarabine. Three different protocols of bendamustine were used [single agent, in combination with rituximab or in combination with vincristine and prednisolone]. The overall response rate was 80% [47% complete response, 33% partial response, and 20% progressive disease]. The drug was well tolerated with very few grade 3/4 toxicities. More than half the patients [9/16] developed a characteristic erythematous, papular skin rash that resolved after completion of chemotherapy. Bendamustine is a safe and useful addition to the drug arsenal against lymphoproliferative disorders. A peculiar skin rash was the commonest side effect noted in Indian patients treated with this drug