ABSTRACT
A 28-year-old woman presented with persistent diarrhea, lower abdominal pain, low-grade fever and general fatigue in 1994. She was admitted to a hospital with suspected inflammatory colitis. Aphthoid mucosal changes were founded on colonoscopy, but the etiology was unknown. Salazosulfapyridine was administered for 3 months, but it was not effective for the abdominal symptoms. In November 1995, pyrexia, lymph node swelling and polyarthralgia appeared, and the patient was admitted to our hospital. Malar rash, photosensitivity, leukopenia, antinuclear antibody and anti-DNA antibody were found. She was diagnosed as having systemic lupus erythematosus and lupus colitis. Prednisolone (30mg/day) was administered, and pyrexia, polyarthralgia and leukopenia were improved, but the abdominal symptoms persisted for 5 weeks. Keisi-ka-syakuyaku-to was administered, and it was markedly effective for relieving persistent diarrhea and abdominal pain. Keisi-ka-syakuyaku-to was continued until February 1999 and the patient's clinical course was satisfactory.