ABSTRACT
Safety and effectiveness of powered food made from <i>Agaricus blazei Murill</i> was evaluated by a randomized human study. 45 healthy subjects were divided into 3 groups in sequence: control, 1 pack and 3 packs/day-administered groups. Each group had 15 persons. They had each packs for 28 days, and followed, in every two weeks, by the evaluation with CTCAE v3.0, QOL (SF36-v2), and biochemical examinations including liver/lung/kidney function, insulin resistance and NK activity and high-sensitivity CRP. None of them had adverse events nor biochemical/lung abnormal examinations. 1 and 3 packs-administered groups improved their QOL, high-sensitivity CRP and NK activity in a dose-dependent manner. These results ascertained safety, and effectiveness of the powdered food made from <i>Agaricus blazei Murill</i> against presymptomatic disorders including metabolic syndrome.
ABSTRACT
The safety and immune potential function of Fucoidan from Cladosiphon okamuranus mixed with mushroom extracts from <i>Grifola frondosa</i>, <i>Phellinus linteus</i> and <i>Cordyceps sinensis</i> were evaluated. Five cancer patients and five elderly people in their 70s ingested the mixed extract for a period of 4 weeks. Results showed significant LDL-C decrease and Th1/2 increase. Moreover, Quality of Life(QOL) related to facialand extremity skin, anxiety, fatigue, cold tolerance and appetite improved significantly. Finally, the clinical test supported the safety of this mixed extracts.<br>