ABSTRACT
The analytic study of 132 patients with molar pregnancies at the Department of Obstetrics & Gynaecology, Siriraj Hospital during 1984-1987 was carried out in order to find out the clinical features, therapeutic interventions, malignancy change and the effect of chemoprophylaxia. There were 132 patients diagnosed as molar pregnancy which makes the prevalence of 1.82 cases per 1,000 pregnancies or 1.96 cases per 1,000 deliveries. Over half of these patients had uterine size of greater than 16 weeks gestation. The uterus was larger than date encountered in 31.8%. The theca lutein cysts with the diameter of larger than 6 cm were encountered in 10.6%. Associated hypertension was encountered in 25.4% while anemia was in 65.2%. Serum thyroxin level of over 18 gm% was found in 22.4% of patients. Malignancy change or persistent trophoblastic disease was found in 23.8% but without significant difference among high and low risk groups. Chemoprophylaxis did not reduce the rate of malignancy change in high risk group. The malignancy change was frequently encountered during the first year post evacuation (93.8%) and became less (6.2%) during the second year.