ABSTRACT
This work was carried out to investigate and compare between the defects of hydrocortisone and prednisolone on the developing alveolar bone of rat offspring, when therapeutic doses are administrated to the mothers during pregnancy. This was done to determine the safety profiles in using these glucocorticoides and this is by direct comparison with controls. From this study it was concluded that hydrocortisone is harmful if administered during pregnancy provided that it causes dangerous effects on the developing alveolar bone. So, it should be avoided completely during the pregnancy period. The alternate day prednisolone drug reduced the undesirable side effects on developing alveolar bone and should be replace the ordinary glucocorticoids if their use is a must