Platelet to lymphocyte ratio as a prognostic factor for epithelial ovarian cancer / 부인종양

OBJECTIVE: To determine whether preoperative platelets to lymphocyte ratio (PLR) could predict disease stage, surgical outcome, and survival in patients with epithelial ovarian cancer (EOC). METHODS: Medical records of EOC patients who had surgery between January 2004 and December 2010 were reviewed. Clinicopathological and complete blood count data were collected. The optimal predictive value of PLR to predict advanced stage, suboptimal surgery, and survival was determined and compared with those of thrombocytosis (> or =400,000 cells/mm3) and neutrophil to lymphocyte ratio (NLR) > or =2.6. RESULTS: A total of 166 EOC patients were included in the study. PLR of 200 yielded better predictive values than those of thrombocytosis and NLR > or =2.6. The area under curve (AUC), sensitivity, specificity, positive and negative predictive values, and accuracy of PLR to predict advanced stage were: 0.66, 59.0%, 72.7%, 65.7%, 66.7%, and 66.3%, respectively. The corresponding values to predict suboptimal surgery were: 0.70, 70.0%, 69.8%, 50.0%, 84.4%, and 69.9%. The patients who had PLR> or =200 had significantly shorter progression-free and overall survivals than those with PLR2.6.

Platelet to lymphocyte ratio as a prognostic factor for epithelial ovarian cancer / 부인종양

OBJECTIVE: To determine whether preoperative platelets to lymphocyte ratio (PLR) could predict disease stage, surgical outcome, and survival in patients with epithelial ovarian cancer (EOC). METHODS: Medical records of EOC patients who had surgery between January 2004 and December 2010 were reviewed. Clinicopathological and complete blood count data were collected. The optimal predictive value of PLR to predict advanced stage, suboptimal surgery, and survival was determined and compared with those of thrombocytosis (> or =400,000 cells/mm3) and neutrophil to lymphocyte ratio (NLR) > or =2.6. RESULTS: A total of 166 EOC patients were included in the study. PLR of 200 yielded better predictive values than those of thrombocytosis and NLR > or =2.6. The area under curve (AUC), sensitivity, specificity, positive and negative predictive values, and accuracy of PLR to predict advanced stage were: 0.66, 59.0%, 72.7%, 65.7%, 66.7%, and 66.3%, respectively. The corresponding values to predict suboptimal surgery were: 0.70, 70.0%, 69.8%, 50.0%, 84.4%, and 69.9%. The patients who had PLR> or =200 had significantly shorter progression-free and overall survivals than those with PLR2.6.

A Randomized Double-Blind Placebo-Controlled Trial to Evaluate the Effectof Vaginal Misoprostol in the Modification of Gross Cervical Anatomy in Patients with Unsatisfactory Colposcopy

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Prevalence of Atypical Glandular Calls of Undetermined Significance (AGUS) from Cervical Pap Smear

Abstract Prevalence of Atypical Glandular Calls of Undetermined Significance (AGUS) from Cervical Pap Smear Thaovalai                      Thavaramara        MD Sumonmal                    Manusirivitnaya    MD Watchara                     Prutthiphongset   MD Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, BMA Medical College and Vajira Hospital Objective : To determine the prevalence and pathology of women who had atypical glandular cells of undetermined significance (AGUS) from cervical Pap smear at BMA Medical College and Vajira Hospital. Study design : Descriptive study. Setting : Division of Gynecologic Oncology, Department of Obstetrics and Gynecology. BMA Medical College and  Vajira Hospital. Subjects : A total of 45,548 women who were checked for cervical Pap smear during Jan 1, 1997 - May 31, 2000. Methods : Women with atypical glandular cell of undetermined significance were reported from Pap smear. The outpatient reports, colposcopic reports, cytological reports and histopathological reports of tissue were collected and reviewed. Main outcome measures : The prevalence of AGUS, colposcopic reports and pathological reports from colposcopic directed biopsy, tissue from endocervical curettage (ECC), fractional curettage (F/C) or loop electrosurgical excision procedure (LEEP) Results : Within the period of study, 57 AGUS-patients were diagnosed from 45,548 Pap smear specimens (0.12%, 95% CI 0.117-0.123%). Thirty-one evaluable patients were investigated with one or several methods; 8 were selected for colposcopy with ECC (25.8%), 6 colposcopic directed biopsy with ECC (19.4%), 8 colposcopic directed biopsy (25.8%), 1 cervical biopsy (3.2%), 1 colposcopy with ECC with LEEP (3.2%), 1 colposcopy only (3.2%), 1 colposcopy and LEEP (3.2%), 1 vaginal biopsy (3.2%), 3 fractional curettage (9.6%) and 1 cervical biopsy followed by LEEP (3.2%). The histopathological reports were negative in 7 cases (22.6%), chronic cervicitis in 9 cases (29.0%), HPV infection in 4 cases (12.9%), CIN I in 2 cases (6.5%), CIN II-III and CIS in 2 cases (6.45%), adenocarcinoma of cervix in 5 cases (16.1%), adenocarcinoma of endometrium in 5 cases (3.2%) and  adenocarcinoma of vulva in 1 case (3.2%). Conclusion : The prevalence of AGUS from Pap smear in this study was 0.12% (95% CI 0.117-0.123%). This prevalence was important and clinically significance due to interconnection between AGUS and malignancy. The patients who have the diagnosis of AGUS are highly recommended for extensive investigation and should be followed up with great care. Key words : atypical glandular cells of undetermined significance, AGUS, Pap smearVajira Med J 2002 ; 46 : 9 - 17