ABSTRACT
The phytochemical investigation of Broussonetia kazinoki roots led to the isolation of ten compounds, including six flavonoids (1–6), two lignans (7 and 8), and two coumarins (9 and 10) by comparing their 1H and 13C NMR spectra with reference values. To the best of our knowledge, compounds 9 and 10 were isolated from this plant for the first time. Among the ten isolates, compounds 2, 4, and 6 exhibited inhibitory effects against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in macrophage RAW264.7 cells with IC50 values of 11.98, 10.16, and 24.06 μM, respectively. Furthermore, compounds 2, 4, and 6 reduced LPS-induced inducible nitric oxide synthase (iNOS) expression in a dose-dependent manner. Pre-incubation of cells with these compounds also significantly suppressed LPS-induced COX-2 protein expression. Compounds 2, 4, and 6 also showed cytotoxic activity against HL-60 cells with IC50 values ranging between 46.43 and 94.06 μM.
ABSTRACT
The phytochemical investigation of Broussonetia kazinoki roots led to the isolation of ten compounds, including six flavonoids (1–6), two lignans (7 and 8), and two coumarins (9 and 10) by comparing their 1H and 13C NMR spectra with reference values. To the best of our knowledge, compounds 9 and 10 were isolated from this plant for the first time. Among the ten isolates, compounds 2, 4, and 6 exhibited inhibitory effects against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in macrophage RAW264.7 cells with IC50 values of 11.98, 10.16, and 24.06 μM, respectively. Furthermore, compounds 2, 4, and 6 reduced LPS-induced inducible nitric oxide synthase (iNOS) expression in a dose-dependent manner. Pre-incubation of cells with these compounds also significantly suppressed LPS-induced COX-2 protein expression. Compounds 2, 4, and 6 also showed cytotoxic activity against HL-60 cells with IC50 values ranging between 46.43 and 94.06 μM.
ABSTRACT
Background: Deltoid contracture can be congenital or acquired. A cross-sectional study has been done in 8 provinces representing three regions in Vietnam. These are Ha Noi, HaTay, Thanh Hoa and Lang Son in the North, Ha Tinh and Da Nang provinces in the central, Tien Giang and Can Tho provinces in the South of Vietnam. Objective: To identify the risk factors of Deltoid contracture in Vietnam from 2006 - 2007. Subject and Method: 29696 people aged from 1 to 60 years old at the time of the survey were examined to diagnose the Deltoid contracture as well as being interviewed by structured questionnaire. Results: There was significant association between contracture of Deltoid muscle and some factors. These are antibiotics injection into the Delta muscle at 0 - 5 years old: OR = 2.93 (1.435,8); Antibiotics type (streptomycin) was injected at 0-5 years old: OR = 45.2 (13.1 - 167); having cicatrix: OR = 73.4 (46.1 - 116.9). There was no significant association between Deltoid fibrosis and vaccination (position and administration). Logistic regression was done to find that antibiotics injection into Delta muscle at 6 - 10 years old and antibiotics type (streptomycin) were significantly associated with Deltoid contracture. Conclusion: Risk factors of Deltoid contracture in this study were antibiotic injection at aged 0 - 5 years old, antibiotic type (Streptomycin) and having cicatrix. There was no significant association between Deltoid fibrosis and vaccination (position and administration).
Subject(s)
Risk Factors , VietnamABSTRACT
Background: Deltoid contracture can be a congenital or acquired condition. There were not any reports on deltoid contracture in English literature until 1960. In 2005 there were 170 children presented at the Viet Nam Pediatric Institute with deltoid contracture. These children came from different provinces, nationwide. The numbers of children who have this condition is increasing, but there were few studies on this problem in Viet Nam. Objectives: To identify the prevalence of deltoid contracture in Viet Nam in 2006-2007. Subjects and method: A cross-sectional study was done in 8 provinces representing for 3 geographic regions of Viet Nam., included Ha Noi, Ha Tay, Thanh Hoa and Lang son in Northern, Ha Tinh and Da Nang in Central and Tien Giang and Can Tho in the Southern region. 29,696 people aged from 1 to 60 years old at the baseline were involved in the study. The subjects were examined to identify the deltoid contracture based on defined criteria. Results: The prevalence of disease was 0.65% (0.83% in men and 0.51% in women). The rate was highest in the group of 6-10 years of age (1.81%). The prevalence was 0.82% in rural and 0.31% in urban area. Cases were found in all but 4 provinces (Da Nang, Tien Giang, Can Tho and Ha Noi) Conclusion: The prevalence of Deltoid contracture in Viet Nam was 0.65% in 2006-2007. It was more likely to occur in men than in women, in age group of 6 \u2013 10 than in other groups and in rural than in urban area.
ABSTRACT
Background: Nerve damage in leprosy reaction occurs very quickly, that can lead to paralysis for many peripheral nerves within 24 hours. Objective: To survey nerve function impairment in leprosy reactions. Subjects and method: 285 new leprosy patients treated from 1996 to 2000 at 22 districts in Ho Chi Minh city had leprosy reaction and estimated nerve functions. This was retrospective cross-section descriptive study. Results: This study included 70.2% men, age 15-45 years (71.9%) and most patients were manual laborers. There were 83.5% multibacillary (MB) and 16.5% paucibacillary (PB). 86.3% Reversal Reaction (RR), Erythemal Nodosum Leprosy (ENL) 13% and both 0.7%. 53% of leprosy reaction happened during Multi-Drug Treatment (MDT), at diagnosis 37.5%, before MDT 7.7% and after MDT 1.8%. Nerve function impairment was 38.2% in leprosy reaction; men had impaired nerve function 1.7 times higher than women (p<0.05). Nerve function impairment in RR and ENL as well as MB and PB were the same (p>0.05). MB (42%) has impaired nerve function higher than PB (26.1%) in RR (p<0.05, OR = 2.05). Conclusions: Leprosy reaction happened to men more frequent than women, essentially in MB and during MDT. One third of cases had nerve function impairment in leprosy reaction and also had a link between sex and nerve function impairment. MB was 2 times the impaired nerve function higher than PB in RR.
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The study on the document and field minutes and direct interview of workers, managers in the Ha noi General Construction company during 1991-1999 have shown that there were72 accidents with 104 persons with injuries in which 23 death, 53 moderate and severe injuries, 28 mild injuries, fall from high accounted for high rate (36,6%), the main cause (89%) of the accident that procedure and regulation of safe work were not obeyed properly.