ABSTRACT
The flavonoids are a large class of polyphenolic compounds found in plants that are known to exhibit biological effects. In the study, the flavonoid 5.7.4-trimethoxyflavone (TMF) extracted from Praxelis clematidea was evaluated for its antibacterial activity. Microdilution method was used for antibacterial assay of the flavonoid and eleven bacteria strains were used in the study for activities. The results were also compared with the standard drug, Chloramphenicol (100 ug/mL). The results obtained showed activity of the flavonoid against Gram positive and Gram negative bacteria.
Los flavonoides son una clase importante de compuestos polifenólicos encontrados en las plantas que se sabe que presentan efectos biológicos. En el estudio, el flavonoide 5.7.4 '-trimethoxyflavone (TMF) extraído de Praxelis clematidea fue evaluado por su actividad antibacteriana. Se utilizó el método de microdilución para el ensayo antibacteriano del flavonoide y once cepas de bacterias se usaron en el estudio de las actividades. Los resultados se compararon también con el fármaco estándar, Cloranfenicol (100 ug/mL). Los resultados obtenidos mostraron actividad del flavonoide contra bacterias Gram positivas y Gram negativas.
Subject(s)
Asteraceae , Anti-Bacterial Agents/isolation & purification , Anti-Bacterial Agents/pharmacology , Flavonoids/isolation & purification , Flavonoids/pharmacology , Plants, Medicinal , Gram-Negative Bacteria , Gram-Positive BacteriaABSTRACT
Aging is associated with a progressive decline of muscle mass, strength, and quality, a condition described as sarcopenia of aging. Despite the significance of skeletal muscle atrophy, the mechanisms responsible for the deterioration of muscle performance are only partially understood. The purpose of this review is to highlight cellular, molecular and biochemical changes that contribute to age-related muscle weakness.
O envelhecimento está associado ao declínio progressivo da massa, força, e qualidade muscular, uma condição descrita como sarcopenia do envelhecimento. Apesar da importante atrofia do músculo esquelético, os mecanismos responsáveis pela deterioração do desempenho muscular são somente parcialmente conhecidos. A proposta desta revisão é ressaltar as alterações celulares, moleculares e bioquímicas que contribuem para a fraqueza muscular associada ao envelhecimento.
Subject(s)
Aging , Muscle Fibers, Skeletal , Myosins , Musculoskeletal SystemABSTRACT
Dietary zinc; calcium; and phytate intakes of 66 rural Malawian children aged 4-6 y were determined during three seasons on the basis of weighed food records and analyzed food composition data. Height and weight measurements were also recorded and hair samples were collected for zinc analysis. Seasonal daily zinc; calcium; and phytate intakes of females ranged from 6.2 +/- 1.7 to 6.8 +/- 2.1 mg (mean +/- SD); from 335 +/- 170 to 401 +/- 257 mg; and from 1621 +/- 660 to 1729 +/- 592 mg; respectively and; for males; 7.0 +/- 1.7 to 8.0 +/- 2.3 mg; 342 +/- 164 to 473 +/- 310 mg; and 1857 +/- 530 to 2161 +/- 684 mg; respectively. Cereals provided greater than 42 percent of dietary zinc. Seasonal mean molar ratios of phytate to Zn and Ca x phytate to Zn (per 1000 kcal (4.2 MJ)) and the median Ca to phytate molar ratio ranged from 24 to 27; 151 to 188 mmol/1000 kcal (4.2 MJ); and 3.1 to 3.4; respectively. Over 78 percent of the children consumed diets with phytate-to-Zn and Ca x phytate.Zn-1 . 1000 kcal-1 molar ratios above values suggested to jeopardize zinc status. Correlations between hair zinc; phytate-to-Zn; and Ca x phytate.Zn-1 . 1000 kcal-1 molar ratios suggest that high phytic acid intakes may compromise zinc status in these children
Subject(s)
Middle Aged , Humans , Male , Weil Disease/diagnosis , Weil Disease/microbiology , Serologic TestsABSTRACT
Se estudia la flora conjuntival y palpebral de 100 sujetos sanos que se desempenan en el Hospital Clinico de la Universidad de Chile, encontrandose cultivo conjuntival positivo en un 49% de los casos.En el parpado se obtuvo un 100% de cultivos positivos. El germen mas frecuentemente aislado tanto en parpado como en conjuntiva fue el Staphylococcus epidermidis (42% y 87%, respectivamente); no se encontro diferencia significativa de la flora al compararla con la literatura revisada que se referia fundamentalmente a sujetos de ambiente extrahospitalario