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China Journal of Chinese Materia Medica ; (24): 437-440, 2004.
Article in Chinese | WPRIM | ID: wpr-256333

ABSTRACT

<p><b>OBJECTIVE</b>To observe the different effects of Puerarin and Daidzein on the expression of proliferating vascular smooth muscle cells, and to discuss the mechanism.</p><p><b>METHOD</b>MT was used to detect the state of VSMC (vascular smooth muscle cell) activity. The expression levels of Survivin, Bcl-xl, Bax and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) messenger RNA (mRNA) were analyzed quantitatively by reverse transcriptase polymerase chain reaction (Rt-PCR).</p><p><b>RESULT</b>Compared with Puerarin groups, VSMC activity in daidzein groups was lower, and the ratio of Bax/Gapdh/Bcl-xl/Gapdh was higher.</p><p><b>CONCLUSION</b>The inhibition effect of daidzein on VSMC proliferation is stronger than that of puerarin.</p>


Subject(s)
Humans , Cells, Cultured , Gene Expression Regulation , Glyceraldehyde-3-Phosphate Dehydrogenases , Genetics , Inhibitor of Apoptosis Proteins , Isoflavones , Pharmacology , Microtubule-Associated Proteins , Genetics , Muscle, Smooth, Vascular , Cell Biology , Myocytes, Smooth Muscle , Metabolism , Neoplasm Proteins , Plants, Medicinal , Chemistry , Proto-Oncogene Proteins c-bcl-2 , Genetics , Pueraria , Chemistry , RNA, Messenger , Genetics , Vasodilator Agents , Pharmacology , bcl-2-Associated X Protein , bcl-X Protein
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