ABSTRACT
<p><b>OBJECTIVE</b>To study the expression of dentin matrix protein 1 (DMP1) and osteoclast in callus at different healing period of mandibular fracture in a adult Wistar rat model.</p><p><b>METHODS</b>The mandibular fracture model of Wistar rats at the left mandibular ramus was established. The callus in the fractured site and the normal mandible were amputated at the 5th, 7th, 14th and 21st day after the fracture. HE staining was used to observe the condition of fracture healing and TRAP staining used to observe the activation of osteoclast. The expression of DMP1 was detected in the callus by using immunohistochemical method.</p><p><b>RESULTS</b>The number of osteoclasts reached a peak from the 14th to 21st day. The expression of DMP1 became very active from the 7th to 14th day.</p><p><b>CONCLUSIONS</b>The expression of DMP1 and osteoclast during fracture healing exhibited time effect.</p>
Subject(s)
Animals , Rats , Disease Models, Animal , Extracellular Matrix Proteins , Metabolism , Fracture Healing , Physiology , Mandible , Metabolism , Mandibular Fractures , Metabolism , Osteoclasts , Physiology , Phosphoproteins , Metabolism , Rats, WistarABSTRACT
<p><b>OBJECTIVE</b>To analyze the clinical feature of temporomandibular joint (TMJ) ankylosis and to investigate the advantage and disadvantage of all kind of surgery methods of TMJ ankylosis for supplying references to the treatment of TMJ ankylosis.</p><p><b>METHODS</b>Aetiology, sex, age at time of treatment, clinical features, radiographic findings, surgical treatment was reviewed and analyzed.</p><p><b>RESULTS</b>Trauma (66.86%, n = 117) and infection (24.57%, n = 43) were the primary causes of TMJ ankylosis. The 10 approximately 19 years age group (44.57%, n =78) occupied the highest frequency in five age groups, one hundred and fourteen (65.14%, n = 114) of the patients presented with lateral ankylosis. They were carried out different surgery method according to their difference of age, aetiology, and so on.</p><p><b>CONCLUSIONS</b>The person at 10 approximately 19 years old had the more feasibility of TMJ ankylosis than others. Trauma was the commonest cause of ankylosis. Different surgical method should be choose according to the different patient.</p>