Comparison of Partial and Radical Nephrectomy for pT1b Renal Cell Carcinoma

PURPOSE: Partial nephrectomy (PN) for patients with T1a renal cell carcinoma (RCC) has increasingly become accepted, although its role for patients with T1b RCC remains controversial. We retrospectively evaluated and then compared the oncologic and functional outcomes of patients with pT1b RCC who were treated with PN or radical nephrectomy (RN). MATERIALS AND METHODS: A total of 70 patients who were diagnosed with pT1bN0M0 RCC between January 1995 and December 2004 were included. The 5-year overall survival (OS), the 5-year recurrence-free survival (RFS), and the 5-year cancer-specific survival (CSS) were compared between the groups. Preoperative and postoperative serum creatinine and estimated glomerular filtration rate (GFR) levels were analyzed to assess renal function. RESULTS: The 5-year OS (92.3% vs. 87.8%, p=0.501), RFS (92.3% vs. 77.8%, p=0.175), and CSS (92.3% vs. 94.5%, p=0.936) of the PN and RN groups were not statistically different. The proportion of patients with decreased renal function was lower in the PN group than in the RN group (PN=0% vs. RN=11.5%). The postoperative change in serum creatinine and the GFR 1 year after nephrectomy was higher in the RN group than in the PN group (PN=0.2+/-0.2, 12.1+/-9.1 vs. RN=0.3+/-0.5, 18.1+/-12.5), but there was no statistical difference. CONCLUSIONS: There were no statistically significant differences in prognosis or renal function between patients treated with PN and those treated with RN for pT1b RCC. PN may be a useful treatment modality for patients with pT1b RCC.

The Prognostic Factors for Patients with pT1a Renal Cell Carcinoma

PURPOSE: Although the prognosis of patients with pT1a stage renal cell carcinoma (RCC) is generally good, some of these patients show distant metastasis. In this study, we intended to identify the perioperative and pathologic prognostic factors for patients with pT1a stage RCC. MATERIALS AND METHODS: A total of 93 patients who were diagnosed with pT1aN0M0 RCC between January 1995 and December 2004 were included. All the patients underwent radical (n=63, 67.7%) or partial (n=30, 32.3%) nephrectomy by a single surgeon. Preoperative data [age, sex, body mass index (BMI), and the presence of symptoms], follow-up duration, surgical methods, and pathological parameters (tumor size, tumor location, histologic type, Fuhrman's nuclear grade and the presence of microvascular invasion, hemorrhage, necrosis, calcification, and a cystic component in the tumor) were retrospectively analyzed to identify which of these were prognostic factors for pT1a RCC. RESULTS: The patients' mean age was 55.0+/-11.4 years and the mean follow-up duration was 63.6+/-31.1 months. The 5-year cancer-specific survival rate and the 5-year recurrence- free survival rate were 100% and 88.1%, respectively. Nine patients (9.7%) showed distant metastasis, but local recurrence was not shown. Fuhrman's nuclear grade (p=0.040, OR=5.147), microvascular invasion (p=0.011, OR=13.500), and tumor necrosis (p<0.001, OR=26.000) had a significant impact on distant metastasis in the univariate analysis. The multivariate analysis subsequently showed that microvascular invasion (p=0.033, OR=17.947) and tumor necrosis (p=0.002, OR=15.922) were independent prognostic factors. CONCLUSIONS: Microvascular invasion and tumor necrosis are the prognostic factors for patients with pT1a RCC.

Nomograms for Prediction of Disease Recurrence in Patients with Primary Ta, T1 Transitional Cell Carcinoma of the Bladder

We developed nomograms to predict disease recurrence in patients with Ta, T1 transitional cell carcinoma of the bladder. Thirty-eight training hospitals participated in this retrospective multicenter study. Between 1998 and 2002, a total of 1,587 patients with newly diagnosed non-muscle invasive bladder cancer were enrolled in this study. Patients with prior histories of bladder cancer, non-transitional cell carcinoma, or a follow-up duration of less than 12 months were excluded. With univariate and multivariate logistic regression analyses, we constructed nomograms to predict disease recurrence, and internal validation was performed using statistical techniques. Three-year and five-year recurrence-free rates were 64.3% and 55.3%, respectively. Multivariate analysis revealed that age (hazard ratio [HR]=1.437, p<0.001), tumor size (HR=1.328, p=0.001), multiplicity (HR=1.505, p<0.001), tumor grade (HR=1.347, p=0.007), concomitant carcinoma in situ (HR=1.611, p=0.007), and intravesical therapy (HR=0.681, p<0.001) were independent predictors for disease recurrence. Based on these prognostic factors, nomograms for the prediction of disease recurrence were developed. These nomograms can be used to predict the probability of disease recurrence in patients with newly diagnosed Ta, T1 transitional cell carcinoma of the bladder. They may be useful for patient counseling, clinical trial design, and patient follow-up planning.

Polyorchidism with Varicocele / 대한남성과학회지

Polyorchidism is a very rare anomaly of the genitourinary tract and about 100 cases have been reported in the literature. Although polyorchidism is associated with undescended testis, inguinal hernia, testicular torsion, hydrocele, epididymitis, varicocele and cancer, the majority of the patients are asymptomatic and present with painless groin or testicular masses. We describe a case of polyorchidism in a 19-year-old man with varicocele and review the literature and current management of polyorchidism.

Long-term Follow-up of Bipolar Transurethral Resection of the Prostate Compared with Conventional Monopolar Resectoscope for Patients with Benign Prostatic Hyperplasia / 대한남성과학회지

PURPOSE: We analyzed the long-term efficacy and safety of bipolar transurethral resection of the prostate (TURP) using the Gyrus(TM) PlasmaKinetic System compared with conventional monopolar TURP. MATERIALS AND METHODS: This study included 54 patients with benign prostatic hyperplasia (BPH) who underwent TURP between May 2003 and April 2004. In all, 28 consecutive patients had bipolar and 26 had monopolar TURP. All patients were assessed by preoperative and postoperative International Prostate Symptom Score (IPSS), uroflowmetry, transrectal ultrasonography, operative time, weight of resected tissue, length of hospital stay, duration of catheter use, change in hemoglobin and serum sodium, and complication rates. RESULTS: Significant improvement was seen postoperatively in both groups, and no difference was observed in the resection time, weight of resected tissue, change in hemoglobin and serum sodium, improvement of IPSS and maximum flow rate (Qmax) or complication rates over the 36-month follow up. However, there was a significant difference in duration of catheter use and hospital stay. Duration of catheter use (2.1 days vs. 3.5 days p=0.012) and hospital stay (2.9 days vs. 4.1 days p=0.024) were shorter in the bipolar group. CONCLUSIONS: Bipolar TURP using the Gyrus(TM) PlasmaKinetic System is as effective as conventional monopolar TURP with the advantages of reduced length of catheter use and shorter hospital stay. Both methods have low complication rates. In the long-term comparison, improvements in IPSS and Qmax after bipolar and monopolar TURP are similar. Thus bipolar TURP may be a good alternative to conventional TURP.

Analysis of Matrix Metalloproteinase-9 Expression in Renal Cell Carcinoma / 영남의대학술지

BACKGROUND: Matrix metalloproteinases (MMPs) are involved in the degradation of the extracellular matrix, which is an important step in tumor invasion and metastasis. A positive correlation between the expression of MMP-9 and aggressive behavior of renal cell carcinomas (RCCs) has been reported. MMP-9 expression in RCCs and adjacent normal kidney tissues were examined in this study. MATERILAS AND METHODS: Twenty-five patients pathologically diagnosed as clear cell RCCs, from specimens obtained at radical nephrectomy, between May 2003 and December 2004 were enrolled in this study. MMP-9 activity was estimated using gelatin zymography, and quantified using a laser densitometer. The results were compared with clinicopathological characteristics. RESULTS: The expression of MMP-9 was significantly elevated in the RCC compared with non-tumor kidney specimens (p4 cm) or vascular invasion were significantly higher than in those without these clinical manifestations (p<0.01). There were also significant differences in the expression of MMP-9 among T stages (p<0.01). The tissue MMP-9 level was the highest in nuclear grade 4, but there was no statistical significance between the histological grades (p=0.17). CONCLUSIONS: These results suggest that enhanced MMP-9 expression contributes to carcinogenesis and tumor progression in the later stages of RCC.

The Clinical Significance of the Expression of Matrix Metalloproteinase-2 and Matrix Metalloproteinase-9 in Renal Cell Carcinoma / 대한비뇨기과학회지

PURPOSE: Matrix metalloproteinases (MMPs) are endogenous peptidases that are capable of degrading various components of the basement membranes. To evaluate the clinical significance of the expressions of MMPs in renal cell carcinomas (RCCs), the MMPs' expression in RCCs and non- neoplastic kidney tissues was examined to evaluate the clinical significance of the expressions of MMPs in renal cell carcinomas (RCCs). MATERIALS AND METHODS: Twenty-two patients with RCCs (the RCC group), and eleven patients with non-neoplastic kidneys (the control group), were enrolled in this study between November 2002 and November 2003. The MMP-2 and MMP-9 activities were estimated using gelatin zymography, and they were quantified using a laser densitometer. The results were compared with the clinicopathological characteristics. RESULTS: The expression of MMP-9 was significantly elevated in the RCC group compared with the control group (p0.05). The levels of MMP-9 expression in the RCC patients with a large tumor (>4cm) or vascular invasion were significantly higher than that in the patients without these clinical manifestations (p<0.01). There were also significant differences in the expression of MMP-9 among the T stages (p<0.01). CONCLUSIONS: The present study shows a close relationship between the expression of MMP-9 and the tumor size and tumor stage in RCC. MMP-9 may be used as a prognostic marker and for the development of a novel treatment modality for RCC.

Transurethral Resection of the Prostate with a Bipolar Tissue Management System Compared to Conventional Monopolar Resectoscope: One-Year Outcome

The purpose of the present study was to evaluate the efficacy and safety of bipolar transurethral prostatectomy (TURP) using the GyrusTM PlasmaKinetic System compared with conventional monopolar TURP. This study included 102 patients with benign prostatic hyperplasia (BPH) who underwent TURP from January 2003 to March 2005. In all, 49 consecutive patients had bipolar and 53 had monopolar TURP. All patients were assessed by preoperative and postoperative International Prostate Symptom Score (IPSS), uroflowmetry, transrectal ultrasonography, operative time, weight of resected tissue, change in serum sodium and hemoglobin, duration of catheter use, length of hospital stay, and complication rates. Significant improvement was seen postoperatively in both groups, and no difference was observed in the resection time, weight of resected tissue, change in serum sodium and hemoglobin, improvement of IPSS and peak flow rate (Qmax), or complication rates over the 12-month follow-up in both groups. There was, however, a significant difference in duration of catheter use and hospital stay. Duration of catheter use (2.28 days vs. 3.12 days) and hospital stay (3.52 days vs. 4.27 days) were shorter in the bipolar group (p = 0.012 vs. p = 0.034, respectively). Our results demonstrate that bipolar TURP using the Gyrus(TM) Plasma Kinetic System is as effective as conventional monopolar TURP with the additional advantage of reduced length of catheter use and hospital stay. Bipolar TURP is a promising new technique that may prove to be a good alternative to conventional TURP in the future.

Bipolar Transurethral Resection of the Prostate: A Comparative Study with Monopolar Transurethral Resection / 대한비뇨기과학회지

PURPOSE: Transurethral resection of the prostate (TURP) using bipolar electrocautery and 0.9% saline is a new technology in the field of surgery for benign prostatic hyperplasia (BPH). This randomized prospective study was conducted to compare the efficacy and safety of the Gyrus(TM) Plasmasect loop bipolar TURP and the conventional monopolar TURP for the treatment of BPH. MATERIALS AND METHODS: This study included 50 patients who were randomized 1:1 to undergo bipolar or monopolar TURP from August 2003 to October 2004. Preoperatively, the patients were assessed by the symptom score, uroflow and transrectal ultrasonography, and the two groups were comparable with regards to these measures and the mean group age. The perioperative and postoperative parameters we studied included the operative time, the resected prostate volume and the change in serum Na and Hb. Postoperatively, the patients were assessed for the symptom score and uroflow at both 1 and 6 months. RESULTS: Postoperative improvements in the symptom score and the Qmax were significant for both groups and the improvements were similar for the two groups. There was no difference in the operative time and resected prostate volume. The serum Na dropped by 4.2mEq/l in the monopolar group, whereas it fell only 1.1mEq/l in the bipolar group (p<0.001). Significant smaller reduction in serum Hb, a shorter postoperative catheterization time and a shorter hospital stay were noted for the bipolar group. CONCLUSIONS: Bipolar TURP using the Gyrus(TM) system is as effective as conventional monopolar TURP and it has additional advantages too. Thus, bipolar TURP may be a good alternative to conventional TURP. However, more follow-up is necessary to assess its long-term efficacy.

Association between Obesity and Prostate Cancer / 영남의대학술지

BACKGROUND: The role of obesity in prostate cancer etiology remains controversial. The aim of this study was to evaluate the relationship between obesity and prostate cancer risk. MATERIALS AND METHODS: Between January 2000 and June 2005, 286 patients suspected of having prostate cancer underwent prostate biopsy. The clinical records of the 286 study patients were retrospectively reviewed with regard to age, Body Mass Index (BMI), serum PSA, TRUS, and prostate biopsy results. They were stratified by BMI into three groups according to the cutoffs recommended for Asian populations: normal, BMI less than 23 kg/m2; overweight, BMI 23 to 25 kg/m2; and obese, BMI greater than 25 kg/m2. RESULTS: As for BMIs, 132 (46.2%) were normal, 95 (33.2%) overweight and 59 (20.6%) were obese. A total of 99 (34.6%) patients were diagnosed as having prostate cancer. In multivariate logistic regression analyses, no significant association was observed between BMI and prostate cancer detection. CONCLUSION: We initially hypothesized that obesity may be biologically associated with increased prostate cancer development. However, our study did not show a significant association between BMI and prostate cancer.

Penile Abscess Caused by Intracavernous Injection of Sildenafil Citrate Oral Pill / 대한남성과학회지

We report the successful treatment by percutaneous aspiration and antibiotics of a penile abscess in an elderly man attributed to misapplication of sildenafil citrate. The etiology, diagnosis, and management of penile abscess are discussed.

Diagnostic Utility of 3-Dimensional Head Mounted Display in Audiovisual Sexual Stimulation / 대한남성과학회지

PURPOSE: This study evaluated the diagnostic utility of a 3-Dimensional head mounted display(HMD) in audiovisual sexual stimulation(AVSS). MATERIALS AND METHODS: A total of 45 men were included in this study: 15 healthy, 15 patients diagnosed with organic impotence, and 15 patients with psychogenic impotence. The NEVA(Nocturnal Electrobioimpedance Volumetric Assessment) system was performed during AVSS with both the 3-D HMD and a conventional monitor. In this study, normal erection was defined as a change in penile blood volume of more than 200% over the baseline for more than 5 minutes. After AVSS, each subject rated his sexual drive as grade I(poor), II(moderate), or III (good). RESULTS: Use of the conventional monitor produced a normal state in 8 men: 5 healthy volunteers(33%) and 3 patients with psychogenic impotence(20%). Use of the 3-D HMD produced a normal state in 23 men: 12 healthy volunteers(80%) and 11 patients with psychogenic impotence(73%). In the healthy volunteers and psychogenic impotence group, the duration of erectile events and percent of volume increase from baseline increased significantly more with 3-D HMD than with the conventional monitor. Compared to results using the conventional monitor, the subjects' sexual drive with 3-D HMD was also significantly increased(p<0.05). CONCLUSIONS: AVSS with 3-D HMD improves the recording of physiological erectile response and may be a valuable tool in making the correct diagnosis of erectile dysfunction.

Clinical Outcome of Prenatal Hydronephrosis / 대한비뇨기과학회지

PURPOSE: The popular use of prenatal ultrasonography has lead to an increase in the diagnosis of hydronephrosis in fetuses. However, there is little data available, in Korea, on the natural progress of prenatal hydronephrosis. Therefore, to help in the management of patients, the follow-up data on fetuses, with antenatally diagnosed hydronephrosis, were analyzed. MATERIALS AND METHODS: Fifty-five (71 renal units) of 102 patients (118 renal units), with antenatally diagnosed hydronephrosis, were available for followed up from the 27th to the 36th fetal week. The follow-up postnatal ultrasonographs were retrospectively reviewed to try and determine the etiology, natural progress, prognosis and treatment of prenatal hydronephrosis. Diuretic 99mTc-DTPA renal and 99mTc-DMSA renal scans, intravenous pyelography and voiding cystourethrography were performed in the unimproved cases. RESULTS: The etiologies of prenatal hydronephrosis were ureteropelvic junction obstruction, VACTERL syndrome, vesicoureteral reflux, duplicated ureter, ureterovesical junction obstruction and polycystic kidney. During the follow-up period, 38 renal units, with prenatal hydronephrosis, improved spontaneously, but 18 units were aggravated. Operations were performed in 13 units. CONCLUSIONS: Many of the fetal hydronephrosis, diagnosed antenatally, disappeared postnatally. It is suggested that fetal, or neonatal, hydronephrosis does not necessarily imply the presence of obstructive uropathy or significant functional abnormality. The fetal antenatally diagnosed hydronephrosis, with clinical symptoms of pyuria, hematuria or a palpable abdominal mass, were often aggravated to a significant uropathy, which required a follow up evaluation and treatment.

Role of Inducible Nitric Oxide Synthase as a Mediator of Renal Ischemia/Reperfusion Injury in the Rat / 대한비뇨기과학회지

PURPOSE: This study was undertaken to elucidate if nitric oxide (NO), produced by inducible nitric oxide synthase (iNOS) following renal ischemia/reperfusion (I/R), contributes to renal injury in rats, and if selective inhibition of iNOS prevents tissue injury following I/R. MATERIALS AND METHODS: Sprague-Dawley rats (male, 200-250gm, n=80) were divided into 4 groups. The groups were pretreated with L-arginine (L-ARG group), N-nitro-L- arginine methyl ester (L-NAME group), aminoguanidine (AG group) or normal saline (control group) before I/R. The renal blood flow was measured using laser Doppler at the left renal pedicle just before clamping the pedicle and at 15, 30, and 45 min after reperfusion. The HandE stain of nephrectomized tissues following I/R was performed for histological scoring of tubular damage and medullary vascular congestion. The expression of iNOS, using reverse transcription-polymerase chain reaction (RT-PCR), in the AG and control groups was determined in the kidney tissues following I/R. RESULTS: The recovery rate of the renal blood flow after I/R was significantly higher in the AG group compared to the controls. From light microscopy, the control group showed attenuated tubular lining epithelial cells, especially in the proximal tubules. However, Glomeruli and individual tubular cells showed no pathological changes. Mild congestion was noted in the medullary area. The L-NAME group showed marked tubular necrosis and medullary congestion. This tubular necrotic injury was compromised in the L-ARG group, but it was almost normal in the AG group. The medullary congestion was still severe in the L-ARG group, but was minimally present in the AG group. RT-PCR of the iNOS in the rat renal tissue revealed an iNOS band at 200bp. No significant difference in the density of the iNOS band was observed between the two groups. CONCLUSIONS: These results suggest that the NO, produced by iNOS following I/R, leads to renal tubular necrosis and medullary congestion, and selective inhibition of the iNOS may prevent renal tissue damage following I/R injury.

A Case of Infected Huge Lymphangioma in Pelvic cavity / 영남의대학술지

Lymphangioma is a benign tumor resulted from abnormal communication between large dermal lymphatic channels and central lymphatic system. The tumor is encountered more often in the neck and axilla and less often in mediastinum, omentum, retroperitoneum, and scrotum. It rarely developed at urogenital system, and there has been no previous description of lymphangioma involving the bladder wall in Korea. We report a case of 35-year-old female with infected huge lymphagioma arising from pelvic cavity and involving bladder wall.

A Case of Infected Huge Lymphangioma in Pelvic cavity / 영남의대학술지

Lymphangioma is a benign tumor resulted from abnormal communication between large dermal lymphatic channels and central lymphatic system. The tumor is encountered more often in the neck and axilla and less often in mediastinum, omentum, retroperitoneum, and scrotum. It rarely developed at urogenital system, and there has been no previous description of lymphangioma involving the bladder wall in Korea. We report a case of 35-year-old female with infected huge lymphagioma arising from pelvic cavity and involving bladder wall.

Effect of Ginseng on Penile Erection: A combined in vitro and in vivo study / 대한남성과학회지

PURPOSE: Korean ginseng (KG) has been used as a general tonic in oriental society. The present study was undertaken to investigate the effect of total saponin (TS), a major extract of KG, and non-saponin components of KG on penile erection for evaluation of the possibility of developing KG as an pharmacological agent. MATERIALS AND METHODS: Strips of rabbit corpus cavernosum were mounted in organ chambers to measure isometric tension, with the treatment of TS and non-saponin components including methanol extracts, ethylacetate extract and H2O extract. We observed the relaxing effect of TS and non-saponin components, which were represented by % relaxation compared to 10-3M sodium nitroprusside-induced relaxation. In adult Sprague Dawley rats, we observed the increase of intracavernous pressure (delta ICP) and duration of tumescence (DT) by intracavernosal injection of TS. RESULTS: TS (1-4mg/cc) significantly relaxed the strips precontracted with phenylephrine (10(-5)M) in dose dependent manner (%relaxation: 5.8-36.7%). Intracavernous injections of TS (0.05mg-3.2mg/0.1cc) induced penile erection (delta ICP: 1.3-21.3mmHg, DT: 0.3-5.2min) in dose dependent manner. The cumulative additions of all non-saponin components at concentrations from 0.5mg/cc to 4mg/cc relaxed the strips in concentration-dependent manner. The maximal relaxing effect were 14.7% in methanol extract, 16.9% in H2O extract, 18.2% in ethylacetate extract. CONCLUSIONS: With the results, ginseng induces penile erection by relaxing corpus cavernosum and suggest that ginseng is not doing its action as a single component but ginseng is doing rather its action as complexes with saponin and non-saponin components.

The Assessment of Sexual Function in Men Who Visited Health Screening Center: a Study Using the Korean Version of IIEF (International Index of Erectile Function) Questionnaire / 대한비뇨기과학회지

PURPOSE: In contrast to previous numerous foreign surveys of epidemiology for sexual dysfunction, only few studies have been reported in our country. This study tried to show the frequencies of sexual dysfunction and objective measure of sexual function using the Korean version IIEF questionnaire. MATERIALS AND METHODS: This study analyzed the answers of 600 men (20-79 years, mean 44.7+/- 0.42 years) who visited health screening center were included. Through the analysis of the survey, the overall frequencies of sexual dysfunction, frequencies of sexual dysfunction by the age decades, in diabetic patients and hypertensive patients, and by alcohol drinking and smoking were obtained. RESULTS: The overall frequencies of sexual dysfunction were 53.3% in erectile function (EF), 80.5% in sexual intercourse satisfaction (IS), 50.5% in orgasmic function (OF), 90.2% in sexual desire (SD), and 84.7% in overall satisfaction (OS). The frequencies of sexual dysfunction in diabetic patients were 93.1% in EF, 96.6% in IS, 79.3% in OF, 96.6% in SD, and 96.6% in OS. In hypertensive patients, the frequencies of sexual dysfunction in EF, SD, OS had high proportion (63.0%, 96.3%, 96.3%, respectively) than control group. CONCLUSIONS: This study proved that the assessment method of sexual function using the Korean version of IIEF Questionnaire is a relatively convenient and effective method which can show objective scores of sexual function. It also showed higher frequencies of sexual dysfunction in comparison to the results of previous reports. And, age, chronic diseases such as, diabetes mellitus and hypertension were considered as the associated factors on sexual dysfunction in this study.

The Effects of Externally Administered Insulin-like Growth Factor-I on Glomerulosclerosis during Compensatory Renal Hypertrophy in Rats / 대한비뇨기과학회지

PURPOSE: Among renotropic agents, a growth hormone (GH) independent insulin-like growth factor-I (IGF-I) improves renal function without inducing glomerulosclerosis and its potential for treating renaldisease is increasing. With this in mind, this study was designed to find out the effects of externallyadministered IGF-I toward preventing glomerulosclerosis after renal volume loss in rats. MATERIALS AND METHODS: Sprague-Dawley rats (110-130gm) were divided into four groups in accordance with 3/4 nephrectomyand/or IGF-I administration. The 3/4 nephrectomy was performed at 30 days after birth, and recombinanthuman IGF-I was administered for 60 days after 3/4 nephrectomy. The change of body weight and wet weight of the remnant kidney were determined. The glomerular planar area and percentage of glomerulosclerosiswere measured. RESULTS: The body weight andthe wet weight of remnant kidney were significantly increased after administration of IGF-I in the3/4 nephrectomy group. The glomerular planar area was significantly increased after administration of IGF-I in the 3/4 nephrectomy group, and significant increase in glomerular planar area was observed in the 3/4 nephrectomy group regardless of IGF-I administration. And the percentage of glomerulosclerosis was significantly decreased. CONCLUSIONS: Thus it is concluded that this study proved that the externally administered IGF-I prevents lomerulosclerosis after severe renal volume loss in rats. It may have a potential to become a useful medical agent for suppressing glomerular sclerotic change and facilitating renal function in chronic renal failure patients.

A Case of Congenital Fibroepithelial Polyp of the Ureter in a Child / 대한비뇨기과학회지

The fibroepithelial polyp of the ureter is a rare, benign tumor. Its pathogenesis is unclear, but most investigators agree that it arises from elements of mesodermal origin within the ureteral wall. Symptoms include hematuria and intermittent flank pain secondary to partial ureteral obstruction. Correct radiologic assessment is crucial to direct surgical management. We report a case of a fibroepithelial polyp of the ureter in a child in whom correct preoperative diagnosis was made by correlating the results of excretory urography, sonography, CT and urine cytology.