ABSTRACT
Objective: To study the effects of ginger oleoresins(GO) on blood lipids in hyperlipidemic mice and the platelet aggregation in rats.Methods: The rat platelet aggregation was induced by ADP and AA in vitro, and the inhibition by GO was tested by light transmission. The animal model of hyperlipidemia was establised by feeding Kunmimg mice with high lipid feed stuff. The effects of GO on serum lipid and hepatic MAD in hyperlipidemic mice was investigated. Results: GO could effectively inhibit rat platelet aggregation induced by ADP and AA in vitro, which were 58.9%,97.5% respectively, and in dose dependant manner. Besides, GO could also significantly decrease serum TC, LDL, AS index and hepatic MDA in hyperlipidemic mice, which were 16.45%, 60.45%,37.30% and 54.27% respectively, and showed no side-effect on liver. Conclusion: Long-term consumption of GO can effectively modulate blood lipids, prevent thrombosis and AS.
ABSTRACT
Objective: To study the hypoglycemic action in diabetic rats by soluble polysaccharides (A), protein components with molecular weights above 60 ku (B),3-60 ku(C) ,and below 3 ku(D) of some pumpkin seeds,arginine(E)and pumpkin seed oil(F). Methods: Ten rats were selected randomly as control ,while the other 150 rats were injected with alloxan 170 mg/kg to induce diabetes.The diabetic rats were divided into 15 groups:the model,A(1000,500 mg/kg),B(300,150 mg/kg),C(300,150 mg/kg),D(300,150 mg/kg),E(100,50 mg/kg),F(300,150 mg/kg),Gilbenclamide(20 mg/kg).The above components were given intragastrically for 10 d and then blood samples were taken to determine serum glucose and insulin, and also to test the glucose tolerance. Results: It was indicated in diabetic rat that the blood insulin level was obviously increased by the soluble polysaccharides , the protein components with molecular weight over 60 ku and below 3 ku after 4 d germination. The blood glucose tolerance was improved by seed oil, protein components with molecular weights 3-60 ku and arginine. Conclusion: The protein components with molecular weights about 3-60 ku have the best hypoglycemic action, in terms of improving the blood glucose tolerance and decreasing the blood glucose level of diabetic rats.