ABSTRACT
Staphylococcus aureus; the most virulent of the many staphylococcal species; has remained a major cause of morbidity and mortality despite the availability of numerous effective anti-staphylococcal antibiotics. S. aureus causes disease through both toxin-mediated and non-toxin-mediated mechanisms. This organism is responsible for both healthcare-associated and community-based infections ranging from relatively minor skin and soft tissue infections to severe life-threatening systemic infections. Patients with diabetes mellitus are at increased risk of invasive S aureus infections. This article focuses on the spectrum of invasive S aureus infections and discusses the clinical features; investigations and management of these infections in patients with diabetes mellitus