ABSTRACT
Regarding to the role of opioid receptors in peripheral cutaneous sensations and central itch procession, this study was designed to determine the efficacy of oral Naltrexone in the treatment of pruritus in patients with eczema in comparison with placebo. Thirty eight patients with eczema complaining of pruritus were studied. Pruritus scores were evaluated. Patients were given the placebo [n=20] or Nalterxone 50 mg [n=18] for a two-week period. During the study, pruritus scores were distinguished by a visual analogue scale [VAS] system and recorded in patients questionnaires three times, at the start of study, after 1 week, and after 2 weeks In the both groups VAS score were decreased, although Naltrexon was more effective than placebo in decreasing the VAS scores, both in 1st week week [P < 0.005] and 2[nd] week [P< 0.001]. Adverse events [mainly nausea and sedation were observed in 3 patients [2 in Naltrexon group and 1 in placebo group] Naltrexone is more effective than placebo in treatment of pruritus in patient affected with eczema. Naltrexone might be considered as an adjuvant remedy in treatment of pruritus