Expression of E-cadherin, syndecan 1, Ki-67, and maintenance minichromosome 3 in tissue lesions of actinic prurigo obtained by incisional biopsy

Actinic prurigo (AP) is an idiopathic photodermatosis; the initial manifestations usually occur during the first decades of life but can appear at any age. Cases are usually diagnosed late once the lesions have exacerbated; due to the extensive involvement of the vermilion border and the etiology, it has been confused with and related to a potentially malignant process. Syndecan-1 and E-cadherin were positive in the epidermis, with moderate-to-intense staining in 100% of samples. Ki67 and MCM3 were expressed in the lower third of the epidermis and showed greater immunolabeling in samples that contained lymphoid follicles (Ki 67: epidermis [17.7% ± 6.79%] and dermis [7.73% ± 6.69%]; MCM3: epidermis [22.92% ± 10.12%] and dermis [6.13% ± 6.27%]). In conclusión AP is a disease in which there is no evidence that the lesions are potentially cancerous. AP cheilitis should not be confused with actinic cheilitis because they are separate entities.

Púrpura de Henoch-Schönlein / Henoch-Schönlein purpura

Resumen Comunicamos el caso de una paciente de 24 años de edad con púrpura de Henoch-Schönlein, quien acudió a nuestro servicio con manifestaciones cutáneas extensas. Cursaba con evolución tórpida y complicaciones gastrointestinales y renales. La púrpura de Henoch-Schönlein es una vasculitis de pequeños vasos que afecta principalmente a pacientes en edad pediátrica, caracterizada por la tétrada de púrpura palpable, dolor abdominal, artralgias o artritis y daño renal. Es una enfermedad sistémica, con depósito de IgA. Por lo general es de alivio espontáneo, pero en algunos casos tiene graves complicaciones, principalmente enfermedad renal crónica. El tratamiento con esteroides se recomienda sólo en casos graves. El reconocimiento temprano de la enfermedad, así como el tratamiento multidisciplinario evitarán complicaciones fatales.

Abstract This paper reports the case of a 24-year-old female patient with Henoch-Schönlein purpura, who presented to our department with cutaneous manifestations. She has torpid evolution, and gastrointestinal and renal complications. Henoch-Schönlein purpura is a small vessel vasculitis that affects mainly pediatric patients, characterized by the tetrad of palpable purpura, abdominal pain, arthralgia or arthritis and kidney injury. It is a systemic disease with IgA. It is usually self-limiting, but in some cases serious complications may appear, mainly chronic kidney disease. Steroid treatment is recommended only in severe cases. Early recognition of the disease and the multidisciplinary management prevent fatal complications.

Coexistencia de vitiligo y psoriasis, serie de casos y perspectivas etiopatogénicas / Coexistence of vitiligo and psoriasis, case series and etiopathogenic perspectives

El vitiligo y la psoriasis se observan con frecuencia en la consulta dermatológica; sin embargo, pese a su alta prevalencia, no es frecuente que ambas se encuentren en un mismo paciente. Presentamos los casos de tres pacientes que exhiben esta situación y realizamos una revisión de la literatura, en cuanto a los aspectos fisiopatogénicos comunes, que podrían contribuir a generar la coexistencia de estas entidades.

Vitiligo and psoriasis are commonly seen in the dermatology clinic; yet, despite their high prevalence, it is infrequent to find them together in the same patient. We report three cases exhibiting this situation and we do a literature review regarding common pathophysiologic aspects that could generate the coexistence of these entities.