Inflammatory pseudotumor-like follicular dendritic cell tumor: an underdiagnosed neoplasia

Follicular dendritic cell (FDC) tumor is an uncommon neoplasm. It generally presents as a slow-growing, painless mass, without systemic symptoms. Histological features usually include low grade spindle cell proliferation. This tumor occurs primarily in lymph nodes, especially cervical and axillary, however, involvement of extranodal sites such as the tonsils, spleen, liver, and gastrointestinal tract has been reported. Inflammatory pseudotumor-like follicular dendritic cell tumor (IPT-like FDCT) is a rare, distinctive histological subtype of this low-grade malignant neoplasm, with consistent Epstein-Barr virus (EBV) association. The differential diagnosis with other fibro-inflammatory tumor proliferations, as inflammatory pseudotumor (IPT) and inflammatory myofibroblastic tumor (IMT), may be challenging. In the present article, two cases of IPT-like FDCT of the spleen are presented, with a broad overview of the literature: one 77-year-old male and one 70-year-old female. A large immunohistochemical panel should be used for diagnosis, as no single specific and totally sensitive markers are available, including markers for CD21, CD23, CD35, CNA42, and clusterin. Individual cases may express one or more of these markers, so that all of them should be investigated. In situ hybridization for EBV is constantly positive. Immunostaining for ALK should be negative, as it is present in roughly half of the cases of IMT. This panel should be used in combination of clinical, laboratory, and topographic evidences. Importantly, inclusion of this lesion as a possible option in clinical and pathological investigation represents the basis for a correct diagnosis (AU)

Instrumentos de avaliação clínica e funcional em cirurgia da coluna vertebral / Instrumentos de evaluación clínica y funcional en cirugía de la columna vertebral / Instruments of clinical and functional evaluation in spine surgery

Alguns dos indivíduos submetidos à cirurgia de coluna vertebral terão desfechos pós-operatório desfavoráveis, independente do êxito técnico. Esse insucesso gera aumento da morbidade e dos custos socioeconômicos. Sabe-se que fatores psicossociais interferem na impressão do sujeito. Com o propósito de identificá-los, tem-se estimulado a busca de preditores prognósticos por meio de instrumentos de triagem. Porém, a eleição do mais adequado pode ser difícil, já que existe um grande número de questionários. Entre os aspectos abordados por eles, podemos citar: incapacidade funcional, qualidade de vida, satisfação, dor, depressão, distúrbios do humor e atividade funcional. O trabalho objetiva revisar as particularidades, indicações e limitações dos instrumentos de avaliação do paciente com doença na coluna vertebral.

Some individuals submitted to spine surgery will have unfavorable postoperative outcomes, regardless of the success of the technical procedure. This failure leads to an increase in morbidity and socioeconomic costs. Also, it is known that psychosocial factors influence the subject's impression. In order to identify these factors, the search for prognostic predictors through screening instruments has been stimulated. However, selecting the most appropriate one may be difficult, as a large number of questionnaires already exist. The aspects addressed by these questionnaires include: functional incapacity, quality of life, satisfaction, pain, depression, mood swings and functional activity. This work reviews the special characteristics, indications and limitations of the instruments used to evaluate patients with spine disease.

Algunos individuos, sometidos a la cirugía de columna vertebral, tendrán resultados posoperatorios desfavorables, independientemente del éxito técnico. Esta falla causa aumento de la morbilidad y de los costos socioeconómicos. Se sabe que factores psicosociales interfieren en las impresiones del sujeto. Con la finalidad de identificarlos, se ha estimulado la búsqueda de predictores pronosticadores mediante instrumentos de selección. Sin embargo, elegir el más adecuado puede ser difícil, ya que existe un gran número de cuestionarios. Entre los aspectos abarcados por estos, podemos citar: incapacidad funcional, calidad de vida, satisfacción, dolor, depresión, disturbios del humor y actividad funcional. El trabajo tiene el objetivo de revisar las particularidades, indicaciones y limitaciones de los instrumentos de evaluación del paciente con enfermedad en la columna vertebral.