ABSTRACT
We present a case of relapsing acute lymphoblastic leukemia (ALL) in the anterior chamber, uveitis masquerade syndrome, which was confirmed by anterior chamber paracentesis and aqueous fluid cytology. Three months previously, the patient developed anterior uveitis without hematologic relapse. The uveitis responded well to topical steroid. After anterior chamber paracentesis, bone marrow relapse was detected. High doses of chemotherapy were prescribed. Ocular radiation was planned but the patient developed septicemia and expired. In our opinion, paracentesis should be performed without delay when uveitis develops in ALL, regardless of systemic relapse. Ocular manifestation may be the only sign of leukemic relapse or may present several months prior to systemic relapse.
Subject(s)
Administration, Topical , Antineoplastic Agents/administration & dosage , Child , Disease Progression , Fatal Outcome , Female , Humans , Leukemic Infiltration , Paracentesis , Precursor Cell Lymphoblastic Leukemia-Lymphoma/diagnosis , Risk Assessment , Steroids/administration & dosage , Syndrome , Uveitis, Anterior/drug therapyABSTRACT
Sixty-one patients (62 eyes) with vitreous hemorrhage were studied. None were associated with diabetic retinopathy or perforating injuries and all required surgical treatment. The patients had dense vitreous hemorrhage with preoperative visual acuity of counting finger or worse in 55 eyes (88.7%). After the operation, a final visual acuity of 6/60 or better was found in 32 eyes (51.6%). The common causes of vitreous hemorrhage were subretinal neovascularization, blunt trauma, branch retinal vein occlusion, post-cataract extraction, retinal detachment with tears, and retinal vasculitis. There was no association between the postoperative visual outcome and either the preoperative visual acuity or the duration of vitreous hemorrhage. The pathological change at the macular area was the main factor which influenced the visual outcome.