ABSTRACT
Pregnancy complicated with systemic lupus erythematosus (SLE) is notoriously variable in its presentation, course, and outcome. Renal involvement is demonstrated in half of patients. Exaggerated by pregnancy on renal function is not concluded. But renal failure is one of the leading causes of death. We report a case of lupus complicating pregnancy that no prepregnancy remission. She developed clinically pre-eclampsia and lupus nephritis in 17 weeks gestation. Flares of disease with deterioration of renal function despite corticosteroid therapy lead to stop pregnancy. Although pregnancy has been terminated, she became worse and died before starting hemodialysis. Histologic study from renal necropsy and clinical manifestation consistented with rapidly progressive glomerulonephritis (RPGN).