ABSTRACT
Abstract: Kaposi's sarcoma (KS) is a multicentric vascular neoplasm, with cutaneous and extracutaneous involvement. Different clinical and epidemiological variants have been identified. The classic form is manifested mainly in elderly men with indolent and long-term evolution, with lesions localized primarily in the lower extremities. We present two cases of classic Kaposi's sarcoma (CKS) in two female patients with extensive, exuberant skin involvement and rapid evolution, with good response to radiotherapy.
Subject(s)
Aged, 80 and over , Female , Humans , Sarcoma, Kaposi/pathology , Sarcoma, Kaposi/radiotherapy , Skin Neoplasms/pathology , Skin Neoplasms/radiotherapy , Vascular Neoplasms/pathology , Vascular Neoplasms/radiotherapy , Biopsy , Disease Progression , Skin/pathology , Treatment OutcomeABSTRACT
Darier's disease is a rare autosomal dominant genodermatosis. It has an estimated prevalence of 1 in 55,000 to 100,000 individuals, regardless of gender. It is characterized by multiple keratotic papules on the seborrheic areas of the trunk, scalp, forehead and flexures, and the clinical picture is worsened by heat, sun exposure, perspiration and mechanical trauma. Histopathology observed loss of epithelial adhesion and abnormal keratinization. About 10% of cases present in the localized form of the disease. We report a case of segmental Darier's Disease Type I and discuss the main characteristics of this condition.
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