ABSTRACT
Any medical diagnosis should take a multimodal approach, especially those involving tumour-like conditions, as entities that mimic neoplasms have overlapping features and may present detrimental outcomes if they are underdiagnosed. These case reports present diagnostic pitfalls resulting from overdependence on a single diagnostic parameter for three musculoskeletal neoplasm mimics: brown tumour (BT) that was mistaken for giant cell tumour (GCT), methicillin-resistant Staphylococcus aureus osteomyelitis mistaken for osteosarcoma and a pseudoaneurysm mistaken for a soft tissue sarcoma. Literature reviews revealed five reports of BT simulating GCT, four reports of osteomyelitis mimicking osteosarcoma and five reports of a pseudoaneurysm imitating a soft tissue sarcoma. Our findings highlight the therapeutic dilemmas that arise with musculoskeletal mimics, as well as the importance of thorough investigation to distinguish mimickers from true neoplasms.
Subject(s)
Adult , Female , Humans , Male , Middle Aged , Aneurysm, False , Diagnosis , Biopsy , Bone Diseases , Diagnosis , Bone Diseases, Metabolic , Diagnosis , Bone Neoplasms , Diagnosis , Cell Proliferation , Diagnosis, Differential , Diagnostic Errors , Giant Cell Tumors , Diagnosis , Hyperparathyroidism , Leukocytosis , Diagnosis , Methicillin-Resistant Staphylococcus aureus , Neoplasms , Diagnosis , Microbiology , Osteomyelitis , Diagnosis , Microbiology , Osteosarcoma , Diagnosis , Sarcoma , Diagnosis , Soft Tissue Neoplasms , Diagnosis , Tibia , PathologyABSTRACT
<p><b>INTRODUCTION</b>Cephalic index (CI), the ratio of head breadth to head length, is widely used to categorise human populations. The aim of this study was to access the impact of anthropometric measurements on the CI of male Japanese university students.</p><p><b>METHODS</b>This study included 1,215 male university students from Tokyo and Kyoto, selected using convenient sampling. Multiple regression analysis was used to determine the effect of anthropometric measurements on CI.</p><p><b>RESULTS</b>The variance inflation factor (VIF) showed no evidence of a multicollinearity problem among independent variables. The coefficients of the regression line demonstrated a significant positive relationship between CI and minimum frontal breadth (p < 0.01), bizygomatic breadth (p < 0.01) and head height (p < 0.05), and a negative relationship between CI and morphological facial height (p < 0.01) and head circumference (p < 0.01). Moreover, the coefficient and odds ratio of logistic regression analysis showed a greater likelihood for minimum frontal breadth (p < 0.01) and bizygomatic breadth (p < 0.01) to predict round-headedness, and morphological facial height (p < 0.05) and head circumference (p < 0.01) to predict long-headedness. Stepwise regression analysis revealed bizygomatic breadth, head circumference, minimum frontal breadth, head height and morphological facial height to be the best predictor craniofacial measurements with respect to CI.</p><p><b>CONCLUSION</b>The results suggest that most of the variables considered in this study appear to influence the CI of adult male Japanese students.</p>