Seizure in the emergency department: Finding the zebra among the horses

Aortic dissection (AD) is a life-threatening emergency that mandates early and precise diagnosis. Seizure as an initial and exclusive manifestation of AD is extremely rare. The prevalence of this is sparsely available in the literature. We report the case of a 68-year-old male patient where the patient presented with seizures and discrepancy of blood pressures in the upper limbs. AD was suspected in this case with an atypical presentation

Preformulations studies and preperation of dithranol loaded solid lipid nanoparticles.

Dithranol belongs to the keratolytic category, which is widely used drug in the treatment of psoriasis. The drug is practically insoluble in water. Many conventional dosage forms for psoriasis treatment have been have been formulated earlier, but they did not show good results. Hence in the present study, it was attempted to formulate dithranol in the form of solid lipid nanoparticle. Solid lipid nanoparticles of dithranol were obtained by adaption of lipid dispersion method. Preformulation studies were performed to check the compatibility of drug and excepient for the preparation of formulation by DSC and no interaction was found. Solubility study, partition coefficient determination, UV analysis, HPLC study, FTIR study were also performed. After the preformulation studies Dithranol loaded solid lipid nanoparticles was also prepared. Hence it was concluded that solid lipid nanoparticle of dithranol could be formulated.