Effect of cortisone administration on the histological structure and lipid content of mouse adrenal cortex

After a single IM injection of cortisone, the adrenal glands of 9 male mice were taken at different periods of time [3 hours, 2 days and 3 days, 3 at a time]. The histological structure and lipid content have been studied. The results obtained in the present study showed marked narrowing of the adrenal cortex compared to the medulla. This narrowing involved only zona fasciculata and zona reticularis. Zona glomerulosa, however, showed relative broadening in width. Depletion of sudanophilic materials initially occurred followed by a marked increase 2 days after injection

Effect of cold on the histological structure ailed lipid content of mouse adrenal cortex

Study of the histological structure and the lipid content of the mouse adrenal cortex after exposure to cold revealed no enlargement of adrenal, slight-dilatation of blood sinusoids and transformation of few cells of the inner zona fasciculata to compact type. Initial intensification of sudan stain was observed 0.5 hour after cold exposure in zona fasciculata extending into zona reticularis, gradual lipid depletion from zona reticularis and inner zona fasciculata, started one hour after cold exposure. Zona glomerulosa did not show any obvious change in lipid content during cold exposure