ABSTRACT
Introduction: Neuromuscular blockers like Rocuroniumbromide can impair respiratory functions during generalanaesthesia. Therefore aim of present study was to find outthe biochemical changes of Rocuronium bromide and othermuscle relaxant in cardiac surgery.Material and Methods: Present study was carried out onsixty (60) patients of different age groups from both sexesscheduled for various cardiac surgical procedures at L.P.S.Institute of Cardiology, GSVM medical college Kanpurduring the period of August 1998 to August 1999. Patientswere classified in 3 equal groups. Muscle relaxants were givenaccording to the group and biochemical parameters like PCo2,PO2, pH etc. were recorded carefully at the interval of two,five and ten minutes.Results: No statistically significant changes were observed inPCo2, pH, Na+, K+ at 2 minutes, 5 minutes and 10 minutes afterthe administration of all three drugs (P >0.05) compared withcontrol values. Statistically Significant changes in PO2 andO2 saturation was observed at 2 minutes, 5 minutes and 10minutes after the administration of Pancuronium (P <0.05).Conclusion: Rocuronium bromide is safer in cardiac surgeryas compared to other muscle relaxants.