ABSTRACT
Background:This study was carried out to determine the growth performance of rats fed graded levels of chitosan supplemented high fat diet.Methods:Thirty male wistar rats weighing between 70g and 90g were purchased and randomly allotted into three (3) treatmentgroups with graded levels of chitosan in high fat diet (1%, 3% and 5%) and three (3) control groups namely: normal diet, high fat diet (HFD) and normal diet +5% chitosan. The feed intakes as well as weight change of the experimental rats were monitored for six (6) weeks.Results:The results obtained showed that the highest level of feed intake and feed efficiency were recorded for animals in group fed 5% level of chitosan supplementation when compared to other treatment groups. Similar result was observed for the weight change (as there was significant reduction in the weight gain with increase chitosan supplementation in HFD) which can be attributed to the efficient utilization of feed consumption.Conclusions:It can be concluded that dietary chitosan prevents excess weight gain in hyperlipidemia and improves the overall nutritional attributes of the experimental diets by improving their feed efficiencies as compared to the control
ABSTRACT
ABO blood groups, Rhesus factors and haemoglobin genotypes are all inherited blood characters. This this study was aimed at investigating the relative incidence of hypertension comorbidly occurring with type 2 diabetes mellitus (T2DM) in ABO/Rhesus blood groups and haemoglobin genotypes in some residents of Abeokuta, South-Western Nigeria. Age and sex matched control subjects (n=150) and patients (n=470) [hypertensive nondiabetics (HND, n=179), normotensive diabetics (ND, n=132), hypertensive diabetics (HD, n=159)] presenting at the Medical Out-Patient Clinic of the State Hospital, Abeokuta, Nigeria were recruited. Standard electrophoretic and haemagglutination techniques were employed in testing the blood samples. Fasting plasma glucose, haemoglobin, plasma creatinine and plasma urea were determined spectrophotometrically. Blood pressure and its component were also determined. Prevalence of hypertension and/or T2DM was observed in subjects with blood O followed by A. The phenotype frequencies of ABO blood group in both hypertensive and diabetic patients and controls (both sexes) are in the order O>A>B>AB. The RhD+ and RhD- distribution were similar in patients and their control counterparts (p > 0.05). The spectrum of haemoglobin electrophoresis among the controls and patients can be shown with a general formula HbAA>HbAS>HbAC>HbSS>HbSC>HbCC except in control female and HD female. The results obtained suggest that there is a strong positive relationship between blood group O and hypertension and/or T2DM. Large studies in other ethnic groups are needed to confirm these results.