ABSTRACT
Psycho-neurological syndrome which is driver’s health status plays a crucial role in ensuring road traffic safety.GoalThe study aims to determine factors leading to traffic accidents by assessing psycho-neurological status of drivers who caused road traffic accidents.MethodsIt is a double-randomized and cross-sectional study. Drivers caused the traffic accidents in the territory of Bayanzurkh District of Ulaanbaatar city between September 2011 and May 2012 were involved.Following investigations were done:• Thorough neurological examination using a prepared clinical pathway;• EEG test;• Assessment of attention, memory, intellectual speed and anxiety of drivers using Lusher test and computer based test.SPSS 18 was applied in data analysis and chi square test was applied in differentiation the proportions.ResultsThe male-female ratio among 394 drivers was 61.9% and 38.1% respectively. 322 drivers (89.04%) had symptoms of episodic headache, dizziness, blurred vision and unsteadiness. 60 drivers (15.2%) had nystagmus which is the main symptom of vertigo (p<0.001). 159 (40.9%) drivers experienced an insomnia. Epileptic and nonepileptic seizure was observed in 155 cases. Out of 394 drivers 243 (61.6%) had symptoms of anxiety. It was observed that 64.6% had low level of anxiety, 27.9% had medium, 7% had high level and 0.4% had severe anxiety. According to the Shultz table, we found that 46.4% of drivers were disintegrated attention and 12.4% (49) were with slow intellectual speed. The hypomnesia was 27.4% (108).Conclusions:1. According to our study, anxiety is dominated among the drivers and attention is disintegrated and slow.2. EEG results (abnormal II and III) proved that drivers who have epileptic and nonepileptic seizures are involved in the traffic accidents.3. Recurrent neurological conditions like headache, dizziness, insomnia, blurred vision and unsteadiness are preconditions for attention dispel, slowing of attention distribution and anxiety of drivers who caused traffic accidents and those recurrent neurological conditions are prevalent among drivers.
ABSTRACT
PUR POSE The aim of the present study was to determine the effective dose of Carbamazepine . according to the serum level concentration. ° METHODS 20 patients with symptomatic focal epilepsy: 10 males and 10 females included in the study. The average age was 3I.8± 8.9 (range 16-50 years).The mean duration of partial seizure was 11.4 ±5.8 years. All patients were using inappropriate doses of Carbamazepine and most of patients were taking it irregularly. Patients were follow- upped during 3 months. Initial dose of treatment was 9.4 ± 2.2 mg/kg. Pharmacokinetic analysis was performed by ABBOTT TDXFLX immunofluorescence autoanalyser in the Laboratory department of the Central Clinical Hospital. The blood samples were collected from patients in the morning before taking the morning dose and after 2 hours. RESULTS Therapeutic effective serum level of Carbamazepine in 8 seizure free patients (40%) was 8.25 ±2.11 ng/ml (range 6.89- 10.77), daily average dose I0.63±2.57mg/ kg. Adverse effects were observed in 7 patients. Average side effect dose was 14.0 ±3.3 mg/kg and 1275±125 mg (p<00l), serum level was 9.4±2.2 ng/ml. One patient had skin rash, drowsiness, ataxia, tremor, diplopia, vomiting and headache. However those syndromes were disappeared when dose of the drug was reduced. Adverse effects registration was performed. Key words: carbamazepine. therapeutic drug monitoring, partial CONCLUSIONS seizure our results clearly demonstrates that is no difference of the response of Carbamazepine between Mongolian patients and patients from other Asian and Western country. The study has been approved at