Success of surgical correction in constant and intermittent exotropias

To evaluate the success rate of surgical corrections of constant and intermittent exotropias. A case series. Al-Ibrahim Eye Hospital, Karachi, from July 2011 to December 2012. Patients having primary exotropia [deviation 15 - 45 prism diopters [PD]] were included. Patients with either constant exotropia or basic intermittent exotropia underwent unilateral surgery of lateral rectus recession [maximum up to 10 mm] and medial rectus resection [up to 6 mm]. Similarly, when patients had intermittent distance exotropia, underwent bilateral lateral rectus recession [maximum up to 10 mm]. Final outcome was considered at the end of 2 months at which achievement of

Efficacy of topical Bevacizumab in high-risk corneal transplant survival

Objective: To evaluate the effectiveness of topical Bevacizumab in preventing neovascularisation on high risk corneal grafts

Methodology: This study was a randomized, controlled, parallel group study, carried out from February 2008 to April 2012 [51 months] at Isra Postgraduate Institute of Ophthalmology and Yasin eye hospital, Karachi. Eyes with high risk corneal transplantation with corneal neovascularization were included in this interventional study/randomized clinical trial. Patients were randomly allocated to 2 groups. Group A and Group B. After penetrating keratoplasty, group A patients received topical bevacizumab [2.5%, 25 mg/ml] which was self-administered 4 times a day for 24 week while group B patients received only sham eye drops. Group B was the control group. Corneal neovascular invasion area i.e. the fraction of area on transplanted cornea in which vessels were present was measured using mathematical software program MatLab. Data analyses was done using SPSS version 19. Frequencies of age gender and groups were measured. Neovascular invasion area and change in visual acuity was compared between the 2 groups using paired t test. P value of less than 0.05 was considered significant

Results: Among the 2 groups mean Corneal neo vascular invasion area was minimum in group A [6.23%] while in group B it was [26.7%]. Maximum number of patients [26] attained visual acuity of 6/36 or better in the topical bevacizumab group compared to 17 sham group

Conclusion: When topical Bevacizumab is used, it reduces the recurrence of neovascularisation and thus helps increasing the frequency of graft survival in cases of high risk corneal transplants

Panretinal photocoagulation with or without sub-tenon triamcinolone in diabetic retinopathy

Objective: To evaluate the visual outcome in patients with diabetic retinopathy who underwent panretinal photocoagulation with or without sub-Tenon triamcinolone acetonide administration

Patients and Methods: Patients with severe non-proliterative diabetic retinopathy or proliferative diabetic retinopathy were randomized either to Group 1 [posterior sub-Tenon triamcinolone acetonide 20 mg injection and panretinal photocoagulation] or Group 2 [panretinal photocoagulation alone]. The primary variable was the change in best-corrected visual acuity at 2 months from the baseline

Results: The difference in visual acuity in the two groups post laser photocoagulation was statistically significant [p < 0.005]. Visual acuity improved in 73% of patients in Group 1 compared with only 6.6% of patients in Group 2

Conclusion: Posterior sub-Tenon triamcinolone acetonide injection has shown promising results in the prevention of panretinal photocoagulation- induced visual loss due to macular edema