ABSTRACT
Objective: To study the effects of Allium sativum extract [ASE] on blood lipoproteins and blood indices in Wistar albino rat model
Study design: Experimental study
Place and Duration of Study: This study was conducted at the Animal House, Isra University Hyderabad from September 2014 to June 2015
Materials and Methods: 80 albino rats were divided into 4 groups; Group 1- Controls [Placebo 0.9% isotonic saline], Group 2- ASE 100 mg/kg, Group 3- ASE 200 mg/kg and Group 4- ASE 300 mg/kg were given orally for 30 days. Blood sample was collected by cardiac puncture. Statistical analysis was performed on SPSS 22.0 by one way ANOVA and post Hoc Duncan test at 95% confidence interval
Results: Triglycerides, total cholesterol, LDLc and HDLc showed statistically significant differences among groups [p =0.0001]. High dose fed ASE showed significant reductions in TAG, TC and LDLc and a rise in HDLc. Also the blood indices showed improvement in ASE treated rats [p=0.001]
Conclusion: The Allium sativum extract reduces triglycerides, total cholesterol and low density lipoproteins and increases high density lipoprotein [HDLc]. Blood indices were also improved in high dose rats