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Background: Peripheral neuropathy is a common treatment related adverse effect and affects long term quality of life. AIM: To study the Carboplatin–Paclitaxel induced peripheral neuropathy in patients with lung or ovarian cancer. Methods: The study was carried out in the Department of Oncology, Government Rajaji Hospital, Madurai, after obtaining clearance from Institutional ethical committee, Government Rajaji Hospital, Madurai.Thirty newly diagnosed patients suffering from Lung or ovarian cancer attending Oncology department were selected. After satisfying inclusion and exclusion criteria,Patient received Injection Carboplatin AUC 6 and Injection Paclitaxel 175mg/m2 . Nerve conduction study was done to assess the peripheral neuropathy. It was done before starting the chemotherapy.Patients with grade 0 neuropathy were included for the study.Nerve conduction study was repeated after each cycle. The time taken to develop peripheral neuropathy was assessed using Cancer Institute – Common Toxicity Criteria version 3.0. The data were analyzed with SPSS statistical software package (Version 16.0 SPSS Inc., Chicago, USA ). Results: There is a statistically significant reduction in sensory nerve (sural) amplitude (SNAP) and latency (p<0.05) indicating significant axonal damage. The time taken to develop peripheral neuropathy was 4 Cycles with Grade 2/4. Conclusions: In this present study , the neurotoxicity induced by Carboplatin–Paclitaxel in patients with lung or ovarian carcinoma was observed. More effective dosing– schedules of treatment decreases the incidence of long lasting peripheral neurotoxicity thus providing better results withlonger survival rate and less disability.
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Background: Chemotherapy induced peripheral neuropathy is a significant disability after the treatment of large number of cancers and they have an impact on quality of life. The aim of the present endeavour was to study the cisplatin-paclitaxel induced peripheral neuropathy in patients with lung or ovarian cancerMethods: The study was carried out in the Department of Oncology, Government Rajaji Hospital, Madurai, after obtaining clearance from Institutional ethical committee, Government Rajaji Hospital, Madurai. Thirty newly diagnosed patients suffering from Lung or ovarian cancer attending Oncology department were selected. After satisfying inclusion and exclusion criteria. Patient received injection cisplatin 60 mg/m2 and injection paclitaxel 175 mg/m2. Nerve conduction study was done to assess the peripheral neuropathy. It was done before starting the chemotherapy. Patients with grade 0 neuropathy were included for the study. Nerve conduction study was repeated after each cycle. The time taken to develop peripheral neuropathy was assessed using Cancer Institute - Common Toxicity Criteria version 3.0. The data were analyzed with SPSS statistical software package (Version 16.0 SPSS Inc., Chicago, USA ).Results: There is a statistically significant reduction in sensory nerve (sural) amplitude (SNAP) and latency (p <0.05) indicating significant axonal damage. The time taken to develop peripheral neuropathy was 3 cycles with grade 3/4.Conclusions: In this present study, the neurotoxicity induced by cisplatin-paclitaxel in patients with lung or ovarian carcinoma was observed, so that early intervention can prevent the permanent neurotoxicity.
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Background: Alpinia galanga is an ayurvedic herb recognized and used across many traditional medicine systems for its analgesic and anti-inflammatory activity. The present study scientifically validates the potential anti nociceptive action of ethanolic extract of Alpinia galanga by chemical, neurogenic and inflammatory nociception model in mice followed by identification of potential lead compound by computational analysis.Methods: The assessment of anti nociceptive action is evaluated by Acetic acid induced abdominal constrictions and Formalin assay on ethonolic extract of Alpinia galanga, followed by 20 compounds with known chemical structure of Alpinia galanga is subjected to computational analysis to predict possible lead compound with desirable pharmacokinetic and drug like features.Results: The percentage inhibition rate of Aspirin (100mg/kg) was 82.15% compared to Alpinia galanga (100mg/kg) 19.63%, (200mg/kg) 33.02% and (400mg/kg) 57.13% by acetic acid induced abdominal constrictions antinociceptive mice model. Alpinia galanga 400mg/kg (71.70%) had comparable percentage inhibition of nociception to standard group indomethacin (88.71%) in formalin induced nociceptive mice model. Among 20 compounds screened for pharmacokinetic and drug like features, Galanal B had the binding free energy -56.664 when compared to control compound 2AZ5-56.000.Conclusions: The Alpinia galanga extract had significant anti nociceptive activity and followed by computational analysis of 20 compounds with known chemical structure predicted Galanal B as lead compound with best insilico pharmacokinetic and drug like features.
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OBJECTIVE: A case series study was conducted for two years from 01 June 2002 to 01 June 2004 to study the efficiency of ultrasound guided hydrostatic reduction in the management of intussusception in children. METHODS: A total of 25 patients who underwent the procedure were evaluated. All the patients were diagnosed by High Resolution Ultrasonography (HRUSG). Continuous monitoring of the progress of reduction during the procedure was done by HRUSG. 500-1000 ml (average 600 ml) of normal saline was used. RESULTS: 24 out of 25 (96%) intussusceptions were successfully reduced. Average time taken was 15 minutes. All the patients were reviewed after 24 hrs for recurrence. None of them showed recurrence within 24 hrs. No complications were observed. CONCLUSION: The study concludes that ultrasound guided hydrostatic reduction is a safe, simple and effective method for treatment of intussusception in children.
Subject(s)
Administration, Rectal , Female , Humans , Hydrostatic Pressure , Intussusception/therapy , Male , Sodium Chloride/administration & dosage , Treatment OutcomeABSTRACT
An attempt has been made to study the release retardant behaviour of chitosan in ibuprofen tablets. Three different ibuprofen tablets were prepared by using 1,3 and 5% chitosan paste. In vitro evaluations were carried out by using dissolution testing apparatus U.S.P (XXI). The dissolution pattern indicated the role of chitosan in sustained release. Bioavailability studies in male beagle dogs clearly showed the sustained nature of release from chitosan based ibuprofen tablet as compared to conventional ibuprofen marketed formulation. Potential use of chitosan as a new matrix forming material for sustained release preparation has been examined. Chitosan, a natural polysaccharide, has structural characteristics similar to glycosamino glycons. Chitosan has been shown to be non-toxic and biodegradable. It is inexpensive and has been explored in the present investigation as a release retarding agent in ibuprofen tablets.