ABSTRACT
This study was aimed to provide pharmacological basis for the medicinal use of Coccinia grandis L. [Cucurbitaceae] leaf aqueous extract in indigestion and constipation using the in vitro assay. The portion of rabbit jejunum was mounted in an organ bath, filled with Tyrode's Ringer solution and spontaneous movements of intestine were recorded on oscillograph and kymograph using isotonic transducer before and after applying drug samples and aqueous leaf extract. This study showed that the C. grandis L. possesses laxative activities along with spasmodic effect in the isolated tissues, mediated partially through activation of muscarinic receptors; thus, this study provides a rationale for the medicinal use of C. grandis L. leaves in indigestion and constipation. The results showed that the aqueous extract of C.grandis L. leaves has a significant spasmodic activity which supports its use in traditional herbal medicine practice. The extract produced an increase in intestinal transit comparable to normal contraction; number of contraction also increased in the presence of extract. Hence, the result indicated a remarkable increasing effect on the movement of intestinal tissues of rabbit in comparison to control
ABSTRACT
Coccinia grandis [kanduri] belonging to Cucurbitaceae family is one of the important plant drug used in Unani system of medicine. It is used by local healers in combination with other drugs to cure skin ailments such as psoriasis, eczema, and scabies. It is also employed in bronchitis and ulcer. Part of plant is recommended in diabetes mellitus. This paper deals with its literature survey regarding diabetes mellitus cultivation, chemical information and medicinal importance. The detailed chemical, histo-chemical color test, botanical features, pharmacognostic parameters and microscopic and macroscopic evaluation of different morphological parts i.e leaf and stem were performed for the identification of genuine samples and for its utilization not only in health care system as medical aid but as raw material in detection of the adulteration in the market sample which is necessary for providing the standardized plants drug material to pharmaceutical industry and, study of the quality control parameters of the drugs
Subject(s)
Pharmacognosy , PhytotherapyABSTRACT
Plant drugs identification is a very crucial problem in the utilization of herbal drugs when used either as a crude drug or as raw material in pharmaceuticals. Various methods are used for the identification and standardization of herbal drugs. Sometime faulty or adulterated drug causes severe health hazard, not only for the patients but also for normal healthy persons. Many drugs which are available in the markets are adulterated and misleading as they are substitutes of the original article. The standardization of herbal drug is therefore necessary to ascertain the genuineness of the herbs. In this paper the methods of standardization [organoleptic and microscopic evaluation] of the drug Holeptelea integrifolia [Roxb] Planch has been presented to establish the quality and purity of this valuable drug