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Indian J Exp Biol ; 2005 Oct; 43(10): 845-8
Article in English | IMSEAR | ID: sea-56001

ABSTRACT

Administration of simvastatin (80 mg/kg, po. evening dose) and gemfibrozil (600 mg/kg, po twice) for 30 days produced significant decrease in the level of reduced glutathione, superoxide dismutase, catalase and increase in the level of lipid peroxidation and various serum parameters (creatine phosphokinase, lactate dehydrogenase, serum glutamate oxaloacetate transaminase, creatinine, urea and blood urea nitrogen). This suggested involvement of oxidative stress in rhabdomyolysis. Increase in the level of reduced glutathione, superoxide dismutase, catalase and decrease in the level of lipid peroxidation and serum parameters after administration of antioxidant CoQ10 (10 mg/kg.ip) proved the protective effect of CoQ10 in rhabdomyolysis.


Subject(s)
Animals , Hypolipidemic Agents/adverse effects , Antioxidants/pharmacology , Blood Urea Nitrogen , Catalase/blood , Coenzymes , Creatinine/blood , Female , Gemfibrozil/adverse effects , Glutathione/blood , Humans , Renal Insufficiency/chemically induced , Lipid Peroxidation , Oxidants/pharmacology , Oxidative Stress , Rats , Rats, Wistar , Rhabdomyolysis/blood , Simvastatin/adverse effects , Superoxide Dismutase/blood , Ubiquinone/analogs & derivatives
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