Comparative study for penile brachial index and intracorporeal prostaglandin E1 infection as two approaches for diagnosis of male importance

The diagnosis of importance in male is of considerable importance in the field of forensic practice. This work was carried out to evaluate the diagnostic value of penile brachial index and interacorporeal prostaglandin E1 injection in the differentiation between psychogenic and organic importance in males. Thirty male patients complaining of impotence were included in the resent study. Full history, general and local examination were carried out for each case, also laboratory studies including, blood sugar levels, urine, prostatic analysis, serum testosterone and prolactin levels were done. Patients involved in the present study were divided according to laboratory investigations and sexual history into two main groups psychogenic and organic group. Penile brachial index was calculated and results were compared with those of intracorpoeal prostaglandin E1 injection in both groups. The patients with normal penile brachial index [above 0.7] tend to give positiveresponse with prostaglandin E1, while patients with poor penile branchial index [less than 0.7] tend to give negative response with prostaglandin E1. Positive response with prostaglandin E1 injection was considered if an erection angle was more than 70 degree sign and maintained more than one hour with good tumescence and rigidity

Inhibition of gentamicin-induced nephrotoxicity by ascorbic acid and pyridoxal hydrochloride

This study was undertaken to compare the capability of blockade of gentamicin nephrotoxicity by either ascorbic acid [vitamin C] or pyridoxal hydrochloride [vitamin B6] and to evaluate whether their combination has a better protective effect than either alone, as manifested by changes in the serum urea and creatinine levels as well as the histological renal changes. For this purpose, 70 male Wister albino rats were equally divided into 7 groups. A negative control group receiving distilled water, a positive control group receiving vitamin C alone, a positive control group receiving vitamin B6, rats receiving gentamicin alone, rats receiving gentalicin as well as vitamin C, rats receiving gentamicin in addition to vitamin B6, and finally rats receiving gentamicin, vitamin C and vitamin B6. Our results showed that, vitamin B6 plays a better role in the protection against gentamicin nephrotoxicity than vitamin C, moreover, the combination of these two vitamins produced a better protection than either vitamin alone. Strict adherence to the prescribed dose of the aminoglycoside preparations especially gentamicin is required. In addition, a combination of vitamin C and vitamin B6 could provide adequate protection against gentamicin-induced nephrotoxitiy

Comparison between the effect of cimetidine and ranitidine on serum prolactin and testosterone levels and testicular structure in male albino rats

The effect of cimetidine and ranitidine [as H[2] receptor antagonists] on serum prolactin and testosterone levels and testicular structure in albino rats were investigated. Thirty healthy male adult Albino rats were used, they were divided into three groups, ten animals each, a control group, and 2 experimental groups [cimetidine and ranitidine groups]. Long term administration of doses equivalent to human therapeutic dose range of both cimetidine and ranitidine were used. In cimetidine group, a dose of 8 mg/Rat was administered intraperitoneally daily for one month. It produced highly significant increase in serum prolactin level [P < 0.001] and also highly significant decrease in serum testosterone level [P < 0.001]. Microscopically the testis showed a decrease in size of the seminiferous tubules and reduction in germinal layers with arrest of spermatogenesis in level of spermatid. Neither Sertoli cells nor Leydig cells showed any significant changes as compared with the control group. In ranitidine group a dose of 3 mg/Rat was administered intraperitoneally daily for one month. This group showed normal serum prolactin and testosterone level, and normal microscopic structure of the testis as compared with the control group