ABSTRACT
Objective: To evaluate and compare the serum levels of visfatin, interleukin-6 and lipid profile in non-obese and obese male patients with coronary artery disease
Study Design: Observational, comparative study
Place and Duration of Study: Punjab Institute of Cardiology and Lahore General Hospital, Lahore, from July to December 2013
Methodology: The participants included 20 non-obese group I with coronary artery disease [CAD] and 20 obese males group II with coronary artery disease [angiographically confirmed]. All the participants were in the age group of 35 - 55 years being non-smokers and non-diabetic. Serum visfatin and interleukin-6 levels were analysed by Enzyme Linked Immunosorbent Assay [ELISA]. Lipid profile was also evaluated. Results were compared with T-test and Mann Whitney U test. The values were considered significant at 0.05 level of significance
Results: Serum visfatin 9.05 versus 3.9 ng/ml and interleukin-6 12.80 versus 0.60 pg/ml levels were significantly [p-value < 0.001 of both] raised in the obese CAD group as compared to non-obese with CAD. Lipid profile also showed raised levels of total serum cholesterol, low density lipoproteins, triglycerides, very low density lipoproteins and low levels of high density lipoproteins in obese group
Conclusion: Significantly raised levels of serum visfatin and interleukin-6 indicate adipose tissue as an imperative source of these adipocytokines involved in inflammation in CAD. Altered lipid profile also seen in obese patients with CAD
ABSTRACT
Objective: to find out the correlation between anthropometric and serum glycemic parameters in a sample of healthy male Pakistani population
Material and Methods: it was a correlational study. Sixty male subjects fulfilling the inclusion criteria were included. Anthropometric parameters including BMI, waist to hip ratio and waist circumference, were measured. Fasting serum glucose and fasting serum insulin were estimated. Insulin resistance was determined quantitatively by HOMA-IR. Serum glycemic parameters were correlated with anthropometric parameters
Results: a significant positive correlation was observed between fasting serum glucose and BMI, waist to hip ratio and waist circumference. A significant positive correlation was observed between fasting serum insulin and waist circumference but there was no significant correlation between serum insulin and other anthropometric parameters. A significant positive correlation was observed between insulin resistance and waist to hip ratio and waist circumference but there was no significant correlation between insulin resistance and BMI
Conclusion: these results provide evidence for linkage between anthropometric and glycemic parameters in apparently healthy, non-obese adults having anthropometric parameters within normal range. Abdominal obesity as measured by waist circumference correlates not only with insulin resistance but also with fasting serum insulin and fasting serum glucose even in healthy subjects
ABSTRACT
Type 2 diabetes mellitus [T2DM] is a predominant public health concern worldwide, accounting for 90% of the cases of diabetes globally. Pathogenesis of T2DM involves insulin resistance, defective insulin secretion and increased glucose production by the liver. Subclinical haemochromatosis has been considered as one of the probable causes of insulin resistance and diabetes mellitus. The aim of this study was to determine and correlate insulin resistance and serum parameters of iron status [serum ferritin and transferrin saturation] in type 2 diabetics. It was a correlational study. This study was conducted on sixty male patients with type 2 diabetes mellitus. Fasting blood sample was taken from each subject and analysed for glucose, haemoglobin, insulin, iron, Total Iron Binding Capacity [TIBC] and ferritin. Insulin resistance was determined by HOMA-IR index. Transferrin saturation was calculated from serum iron and TIBC. Data was analysed using SPSS-17. There was significant positive correlation between insulin resistance and transferring saturation, but there was no significant correlation of insulin resistance with blood haemoglobin, serum iron and serum ferritin in type 2 diabetics. Correlation between insulin resistance and transferrin saturation reveals that iron has negative impact on insulin sensitivity in type 2 diabetics
Subject(s)
Humans , Male , Insulin Resistance , Hemochromatosis , Ferritins , Transferrin , IronABSTRACT
To diagnose isolated tuberculosis of the sternum in patients presenting with signs and symptoms suggestive of tuberculosis. A prospective study conducted at Jawaharlal Nehru Medical College [JNMC] Hospital, Aligarh, India from July 2000 to July 2006 of 2512 patients presenting with a suspected case of tuberculosis. Cases were confirmed using different investigations along with treatment of the patients with antitubercular treatment [ATT], with further follow up for next 2 years. Nineteen patients were suffering from isolated tuberculosis of sternum. The main presenting feature was retrosternal discomfort [100%] while 14 [73.6%] patients presented with a cold abscess of sternum. All the patients were treated successfully with 12 months of ATT and followed up for 2 years for any relapse. Although tuberculosis of sternum is rare, it should be considered as an important differential diagnosis in patients presenting with chronic lesions of the sternum, particularly in endemic/developing countries. Twelve months of treatment with ATT is optimal for achieving cure without any risk of relapse