ABSTRACT
Introduction: Pancreatic cancer is dominated by exocrine pancreatic cancer. The most common histological type isadenocarcinoma in 95% of cases. Surgery remains the only curative treatment. However, only 20% of pancreatic cancers arejudged to be operable at the time of diagnosis.Aim: The aim of this study was to comprehensively analyze the histopathological spectrum of pancreatic lesions.Materials and Methods: This retrospective study was conducted in all pancreatic lesion cases. The specimens were examinedexternally and then opened as per the conventional method after overnight fixation in 10% formalin.Results: A total of 26 (52%) biopsy samples were obtained, 4 (8%) cyst excision, 11 (22%) partial pancreatectomy, and9 (18%) Whipple’s procedure specimen. Mean tumor size was 2.64 cm range 0.6–13 cm. Of the various gross morphologicaltypes seen, the most common was polypoid. Malignant lesions were 16 (32%) cases of adenocarcinoma, 6 (12%) cases of theneuroendocrine tumor, and 4 (8%) cases of solid pseudopapillary tumor of the pancreas.Conclusion: Histopathology is mandatory in many of the lesions which present as cystic and solid masses. It also aids inavoiding unwanted radical surgeries in patients which will increase the morbidity and mortality.
ABSTRACT
Introduction: The main feature of the vast majority of leprosy biopsy specimens is a granulomatous infiltrate that has differentfeatures according to the form of leprosy, the time and site of the biopsy, the presence of a leprosy reaction, and therapy.Aim: This study aims to analyze the clinicohistopathological correlation in different types of leprosy.Materials and Methods: Skin biopsies were taken from clinically suspected patients. The tissue section was stained routinelyby hematoxylin and eosin. Aspecial stain like modified Fite-Faraco (FF) was done to demonstrate lepra bacilli. Histopathologicalfindings were graded into tuberculoid, borderline tuberculoid, midborderline, borderline lepromatous (BL), and lepromatous (LL),according to Ridley and Jopling scale. The clinicohistopathological correlation was done.Results: In 162 cases, 154 cases were confirmed as leprosy in histopathology. LL leprosy was more common 26.6% followedby BL leprosy 25.3%. In histopathologically confirmed leprosy cases, 103 cases (67.6%) were positive in FF stain.Conclusion: Some degree of overlap between different types of leprosy, both clinically and histopathologically, correlation ofclinical and histopathological features along with bacteriological index appears to be more useful for accurate typing of leprosythan considering any one of the single parameters alone.