ABSTRACT
Background: hypertensive disorders in pregnancy are one of the high risk pregnancies. There are considerable evidences about the role of platelet in preeclampsia in pathophysiology. In this study the mean of volume platelet and count in normal pregnant women and preeclamptic women were compared
Materials and methods: in a case - control study 35 normal pregnant women who matched in age, gestational age, and gravity were compared with 35 preeclamptic women to determine the mean volume platelet and count from 2003 to 2005 on pregnant women who admitted at obstetric ward of Taleghani Hospital and outpatient department were entered the study
Results: totaly 70 pregnant women [35 case of preeclamptic women and 35 control groups] , were evaluated. Mean age in normal pregnant women were 27+/- 5.4 years and in preeclamptic group was 27.2 +/- 5.3 years [range:17-38 years]. The Number of gravity of the patients Were between 1 to 8.the mean of gestational age in both group were 32.7 +/- 5.1 weeks[range:20-41 weeks]. In normal group no one has platelet count less than 150.000/[micro]l and in none of them means platelet volume was more than 10fm. In preeclamptic group in 16[45.7%] cases platelet count was less than 150000/[micro]l and in 9 [25.7%] mean platelet volume of >/= 10fl was obtained. In normal pregnant women mean platelet count was 208300/[micro]l+/- 4600 and mean of mean platelet volume was 8.2+/-0.63fl. In preeclamptic women mean platelet count was 154000/[micro]l+/-84000 [P<0.005] and mean of mean platelet volume was 9.2 +/- 0.84 fl. [P<0.0001]
Conclusion: decrease in count and increase in size of platelets probably precede preeclampsia
ABSTRACT
Background: the aim of this study is to explain the epidemiologic characteristic of the patients with Gestational Trophoblastic Tumors [GTT]. GTT is among the rare human malignancies that can be cured even in the presence of widespread metastasis. Although persistent GTT usually occurred after molar pregnancy, it can occur after term pregnancy, abortion and ectopic pregnancy
Materials and Methods: in a descriptive study based on existing data, we reviewed the records of 85 cases of GTT in Imam Hossein, Taleghani and Mirza Koochak Khan teaching hospitals in Tehran during 1992 to 2002 .The epidemiologic variables taken into consideration include: age, parity score, antecedent pregnancy, mean serum Beta Human Chorionic Gonadotropin [HCG] level before therapeutic interventions, clinical manifestations, probable metastasis and staging
Results: mean age of the patients with GTT was 30.8 with standard deviation[SD] of 10.9 .80% of them were multipara and 80% developed GTT following molar pregnancy .64.3% of cases were in stage 1 [limited to uterus] and the other 35.7% of cases had distance metastasis to lung[16.7%], brain[8.2%], liver[8.2%], kidney[2.4%] and other sites. surprisingly, levels of [beta]HCG were less than 5000mIU/mL in more than half of the patients before therapeutic interventions
Conclusions: in this study most cases of GTT occurred after molar pregnancy, while it could be prevented by following [beta]HCG levels .More over, mean level of serum [beta]HCG was too low even in the presence of metastasis which needs further investigations