Birth Weight and the Development of Functional Gastrointestinal Disorders in Infants / 대한소아소화기영양학회지

Purpose@#To assess the association between birth weight and the development of functional gastrointestinal disorders (FGIDs) in the first year of life. @*Methods@#This is a secondary analysis of a prospective cohort multicenter study including neonates, consecutively enrolled at birth, and followed up for one year. At birth all infants were classified by birth weight as extremely low (ELBW), very low, or low when 90th percentile) for gestational age. FGIDs were classified according to the Rome III criteria and assessed at 1, 3, 6, and 12 months of life. @*Results@#Among 1,152 newborns enrolled, 934 (81.1%) completed the study: 302 (32.3%) were preterm, 35 (3.7%) were ELBW, 104 (11.1%) were SGA, 782 (83.7%) were AGA, and 48 (5.1%) were LGA infants. Overall, throughout the first year of life, 718 (76.9%) reported at least one FGID. The proportion of infants presenting with at least one FGID was significantly higher in ELBW (97%) compared to LBW (74%) (p=0.01) and in LGA (85.4%) and SGA (85.6%) compared to AGA (75.2%) (p=0.0001). On multivariate analysis, SGA was significantly associated with infantile colic. @*Conclusion@#We observed an increased risk of FGIDs in ELBW, SGA, and LGA neonates. Our results suggest that prenatal factors determining birth weight may influence the development of FGIDs in infants. Understanding the role of all potential risk factors may provide new insights and targeted approaches for FGIDs.

Prediction of Transient or Permanent Congenital Hypothyroidism from Initial Thyroid Stimulating Hormone Levels

Objective:To identify factors that discriminate between transient and permanentcongenital hypothyroidism. Methods: Retrospective evaluation of 58 children withcongenital hypothyroidism and eutopic thyroid gland. Gender, gestational age, birth weight,TSH and serum thyroxine levels at diagnosis and L-thyroxine dose at 12 and 24 months ofage were analyzed. Results: Median (IQR) initial TSH levels were 73.3 (276.5) ?IU/mL inpermanent hypothyroidism and 24.24 (52.7) ?U/mL in transient hypothyroidism (P =0.0132).The optimum cut-off value of initial TSH to predict transient hypothyroidism was 90 ?IU/mL.Mean (SD) L-thyroxine doses at 24 months of age were 2.64 (0.98) ?g/kg/day in permanenthypothyroidism and 1.91 (0.65) ?g/kg/day in transient hypothyroidism. Requirement of L-thyroxine dose at 24 months of ?0.94 ?g/kg/day had the highest sensitivity (100%) to predicttransient hypothyroidism. Conclusions:L-thyroxine doses at 24 months can predicttransient hypothyroidism in patients with eutopic thyroid gland earlier than at 36 months.