ABSTRACT
To evaluate serum vutamins levels and its asociation with obstetrics and perinatal results in HIV infected pregnant women. observational and prospective study carried out al Division of Infectious-Contagious Disease in Gynecology and Obstetrics of the University of Sâo Paulo, involving 57 pregnant women dividied into 3 groups: Group 1, with 12 normal pregnant women, it was the control group; Group 2, with 20 HIV infected pregnant women, using ZDV; and Group 3, with 25 HIV infected pregnant women, using therapy I contend ZDV, 3TC and nelfinavir. The evaluation of the serum vitamin level was obtained three times during pregnancy at equidistant time intervals and in the inmediate period after birth. We also evaluated the levels of this vitamin and hemoglobin in the blood of the umbilical cord. We obtained maternal and newborn infant anthropometric data, as well as the counting of lymphocyte TCD4 and viral load of the HIV during the pregnancy. Reduced serum vitamin levels were observed in the Group 1 (25 per cent), the Group 2(29,4 per cent) and the Group 3(28,6 per cent). Association was not observed between serum levels of maternal retinol and the duration of the gestation in groups 2 and 3. In groups 1 and 3, an association was observed between the maternal concentration of retinol and the newborn hemoglobin (p=0,05). In distinct way to the Control group, association was not observed in gestations of Group 3(p=0,06). We observed hight prevalence of hipovitaminosis A in the population of this study, regardless og antiretroviral scheme used
Subject(s)
Pregnancy , Female , HIV , Pregnancy , Vitamin A , Vitamin A Deficiency , Brazil , Nutritional Sciences , ObstetricsABSTRACT
No presente estudo, retrospectivo, observou-se um aumento significativo nos níveis séricos de ácido úrico de pacientes alcoólatras desnutridos, submetidos à nutriçäo enteral. Pacientes do Grupo I (n=21) receberam dieta à base de sacarose a 85% aminoácidos a 10% e infusäo I.V. de lipídeos a 10%, duas vezes por semana; os pacientes do Grupo II (n=7) receberam dieta à base de extrato aquoso de soja de preparo artesanal, gordura de coco e açucar de milho. Näo houve fonte exógena de purinas ou RNA e todos os nutrientes, incluindo-se energia e proteínas foram administrados em quantidades recomendadas. No Grupo I, os níveis médiosde ácido úrico aumentaram de valores iniciais de 5,8 mg% para 6,2 mg% (p=0,1) no 7§ dia e 7,3 mg% (p<0,001) no 14§ dia (Grupo I). No Grupo II, os aumentos foram de 5,4 mg% para 9,0 mg% e 8,9 mg% (p<0,001) no sétimo e 14§ dias, respectivamente. Três pacientes do Grupo I (14,3%) e 3 pacientes do Grupo II (42,8%) tiveram hiperurinemia no 14§ dia de nutriçäo enteral,. Aumentos significativos e mantidos de ácido úrico sérico näo tem sido relatados na literatura em associaçäo com a nutriçäo enteral e diferem da hipouricemia, causada pela nutriçäo parenteral. As possíveis causas do fenômeno säo discutidas, sugerindo-se que os hidratos de carbono na dieta sejam os causadores desse distúrbio