ABSTRACT
The advances in the study of the role of growth hormone (GH) in the field of diabetes, confining clinically its glucoregulatory and diabetogenic effects, plus relevant findings in basic research, open new perspectives. The influence of GH on Type-2 diabetes is based on the classic experiments of Houssay's school, the diabetogenic action of GH and its transferrin mediator. Since GH is under hypothalamic command, the permanent GH hypersecretion is the pathophysiological evidence for hypothalamic dysfunction. Thus, type-2 diabetes is postulated as a reversible type of clinical idiohypohyseal diabetes. Different degrees of hypophyseal diabetes can be observed, with the interplay between insulin-growth factor-l and transferrin in some cases of acromegaly. In cases of selective predominance of GH and the consequent chronic elevation of transferrin levels, idiohypophyseal diabetes would develop. Therefore, this type of diabetes should be treated with hypothalamic GH inhibitors. In this line of thinking, the use of somatostatin analogs looks promising
Subject(s)
Humans , Animals , Diabetes Mellitus, Type 2/physiopathology , Transferrin/pharmacokinetics , Somatostatin , Human Growth Hormone , Diabetic Nephropathies/physiopathologySubject(s)
Humans , Stress, Physiological , Benzodiazepines , Diabetes Mellitus , Hyperglycemia , Stress, PhysiologicalSubject(s)
Humans , Delivery of Health Care , Ethics, Medical , Health Policy/trends , Research , Professional Practice/trendsABSTRACT
Se presenta el estrés en la perspectiva de una respuesta automatizada relacionada con comportamiento heredado, donde la amenaza ha desempeñado el papel fundamental. Por lo tanto, sólo los agentes ofensivos o desagradables son aceptado como estresores, un punto que tiene importancia teórica especial. Para la respuesta neuroendocrina, considerada como componente fisiológico intermediario en la reacción del estrés, se afirma que es típica, por lo que no procede definiria como inespecífica. Por otra parte, se ha demostrado que la calidad del agente estresante comanda la respuesta y que únicamente el estresor incontrolable, de curso crónico, induce estrés que se acompaña de inmunodepresión. Esto junto con explicar la posible transformación de un evento patogénico en patológico, pone también en evidencia que la respuesta del estrés tiene especificidad
Subject(s)
Humans , Stress, Psychological/complications , Chronic Disease , Stress, Psychological/etiologyABSTRACT
Dr. George Washington Corner discovered progesterone and was a pioneer in several areas of the endocrinology of reproduction. The present article on the work and life of Dr. Corner, is a tribute rendered to him by Dr. Vargas Fernández, one of his disciples. A selected list of references on Dr. Corner's work is included by the author.