Venovenous Hemodiafiltration and Hypothermia for Treatment of Cerebral Edema Associated With Hyperammonemia.

We report a 50-hour-old newborn with inborn urea cycle disorder and hyperammonia of 2320 μmol/L. The pharmacological treatment of the first metabolic crisis was combined with venovenous hemodiafiltration and therapeutic hypothermia to rescue the patient from a life-threatening cerebral edema.