Pyoderma Gangrenosum: A Case Series.

Pyoderma gangrenosum is a rare, ulcerative, non-infectious neutrophilic dermatosis, commonly associated with underlying systemic disease. The features of pyoderma gangrenosum are not specific histopathologically and for this reason the diagnosis is based on clinical feature. The systemic administration of corticosteroids is the mainstay of treatment. We present five cases of pyoderma gangrenosum of age group ranging from 2 to 75 years. One of these patients was HIV-infected, and one was having discoid lupus erythematosus. The lesions were present on thighs in 3 cases, over back in one and breast in one. Biopsy showed central necrosis with multiple neutrophilic abscesses in epidermis. The dermis showed dense neutrophilic infiltration in both superficial and deep dermis. The lesions responded well to oral corticosteroids except in the case of HIV-infected patient in which minocycline showed considerable improvement.

Subacute Papular Cutaneous Sarcoidosis Resistant to Conventional Therapy: A Case Report.

Sarcoidosis is a multisystem disease of obscure etiology that may involve almost any organ system; therefore, it results in various clinical manifestations. We are presenting a case of 60-year-old female complaining of multiple raised skin colored, to reddish lesions over face and few lesions over neck and extremities since 4 months cutaneous examination revealed multiple well defined skin colored to erythematous papulo-nodular lesions involving whole face with few discrete papular lesions over neck and extremities. Nasal skin was globular, studded with multiple nodules suggestive of lupus pernio. Histopathology showed many non-caseating naked epithelioid cell granulomas of variable sizes in the dermis. He was given oral methylprednisolone 16 mg twice daily after meal along with oral methotrexate 15 mg once in a week and tablet hydroxychloroquine 200 mg twice daily with keeping an eye over related adverse effects of all prescribed drugs. Still patient did not get remission after 6 months of a complete therapy. Due to the rarity of this disorder and its non-responding nature and course with conventional modalities of treatment made us to report this article for further studies and research.

Buschke–Lowenstein Tumor in a Human Immunodeficiency Virus Positive Patient: A Rare Case Report.

Buschke–Lowenstein tumor, otherwise known as giant condyloma acuminata, presents as an asymptomatic, papillomatous growth on the genitalia or the perianal area that grows to a large size. A 28 year old male HIV seropositive patient presented to outpatient department clinic with complaint of large painfull mass in pubic, peno-scrotal & anogenital region with pus, bleeding and fetid odour since 1 year Histopathological examination revealed hyperkeratosis, parakeratosis, acanthosis & papillomatosis. A wide surgical excision was performed with removal of 80% of tumor and for rest of the tumor podophyllin 20% was prescribed.