Biopotency and toxicity of diverse group of insecticides under laboratory condition against sunflower defoliator Spilarctia obliqua (Walker)

The biopotency and toxicity of two groups, conventional and newer insecticides [eight commercial insecticides] were determined against Bihar or Common hairy caterpillar (BHC) Spilarctia obliqua (Walker). Experiment carried out in the laboratory by exposing BHC larvae to insecticides. Biopotency was measured at different time intervals from 12-72 h after insecticidal application showed that all of the insecticides outperformed the control. At 48 h after imposing, the highest mortality percentage (100) was observed on spinetoram 11.7 SC and chlorfenapyr 10 SC, which are comparable to cyantranaliprole 10.26 OD, followed by chlorantraniliprole 18.5 SC, ?-cyhalothrin 5 EC and chlorpyriphos 20 EC, with the lowest mortality percentage observed on tolfenpyrad 15 EC (66.67 %). In chlorantraniliprole, cyantranaliprole, spinetoram, tolfenpyrad, fipronil, chlorfenapyr, ?-cyhalothrin and chlorpyriphos, respectively, the toxicity level of insecticides was calculated based on median lethal concentration (LC50) values of 0.36, 0.48, 0.52, 0.50, 0.69, 0.98, 1.43 and 3.82 ppm. The overall conclusion of this trial was that spinetoram 11.7 SC and chlorfenapyr10 SC are the best chemicals for controlling the early stages of BHC larvae. In comparison to traditional insecticides, new insecticides have the highest level of toxicity

Non-venereal genital dermatoses and their impact on quality of life—A cross-sectional study

Background: Lesions on the external genitalia could be venereal or non-venereal. Non-venereal genital dermatoses are common and may cause considerable anxiety to patients, particularly if noticed after sexual intercourse. However, this aspect has not been studied much till now. Objectives: Our study proposes to describe the profile of non-venereal genital dermatoses and determine their impact on quality of life both social and sexual, using the dermatology life quality index questionnaire. Methods: We recruited patients aged 18 years and above, who were diagnosed to have non-venereal genital dermatoses during the study period. A detailed history was obtained and clinical examination done with relevant investigations when necessary. The dermatology life quality index was assessed and graded in all patients using Finlay dermatology life quality index questionnaire. Results: A total of 293 patients with non-venereal genital dermatoses were seen and 25 different dermatoses were observed. Men 242(82.6%) outnumbered women. The commonest age group affected was 31–50 years 144(50%). Chronic inflammatory dermatoses 135(41.6%) constituted the majority of cases. Scrotal dermatitis 46(15.7%), lichen simplex chronicus 37(12.6%), vitiligo 31(10.6%) were seen most frequently. In the study group, 111(37.9%) patients had moderate and 133(45.4%) had large impact on the quality of life. Erectile dysfunction was seen in 48(19.8%) men and 9(3.7%) had premature ejaculation. A significant effect on dermatology life quality index was found with increasing age (P = 0.007), positive marital status (P = 0.006), history of unprotected sex (P < 0.001), history of recurrences (P = 0.002) and venereophobia. (P = 0.008). Limitations: The number of women in the study group was less compared to men and we could not ascertain the type of sexual dysfunction in them. Conclusion: Non-venereal genital dermatoses are common, more so among men. They have a significant impact on the quality of life of the individual. Recognizing and addressing this problem will help in managing these patients effectively.

STUDY OF CORRELATION OF ABO AND RH INCOMPATIBILITY WITH RISK OF NEONATAL HYPERBILIRUBINEMIA IN A TERTIARY CARE HOSPITAL

Background: Hyperbilirubinemia in a neonate is one of the most common problems that may occur in 60-70 % of term and 80% of preterm babies. It is known to be associated with significant morbidity like neonatal bilirubin encephalopathy and even death. Clinically, and almost exclusively ABO incompatibility occurs in 'A' and 'B' blood group babies of O '+ve' mothers. These babies are reported to be at high risk of severe hyperbilirubinemia. So early intervention, at proper time, is mandatory to prevent these sequelae Methods: The aim is to determine the frequency of ABO and Rh blood group incompatibilities and associated incidence of hyperbilirubinemia for the purpose of instituting intervention for better neonatal outcomes. It was a descriptive cross-sectional study that includes 102 neonates born to mother with O or Rh-negative blood group admitted in the post-natal ward for routine newborn care. Serum bilirubin was documented in icteric neonates. Results: The incidence of ABO incompatibility in our study was 33.33% and of Rh incompatibility was 4.9%. In ABO and Rh incompatibility group, 41.17% and 20% new born respectively developed clinical jaundice. In ABO incompatibility group, majority, 64.28% did not require treatment, whereas in Rh incompatibility group 100% required treatment. In both ABO and Rh incompatibility exchange transfusion was not required. In ABO and Rh incompatibility, all new-born treated well and no kernicterus was seen. Conclusions: In ABO incompatibility, if jaundice develops, it remains in physiological limits. In presence of some aggravating conditions may present as pathological jaundice. It results in significant morbidity but no mortality, so prevention of aggravating factors is very important, in case of ABO and Rh incompatibility

Takayasu arteritis presenting with massive cerebral ischemic infarction in a 15-year-old girl: a case report

Takayasu arteritis is a relatively rare type of large-vessel arteritis that primarily affects the aorta and its major branches, the coronary arteries, and the pulmonary arteries. Depending on the different groups of blood vessels involved in the disease process, the clinical presentation of Takayasu arteritis varies. Here we report a case of a girl presenting with a debilitating massive cerebral ischemic infarct that turned out to be a relatively rare first presentation of Takayasu arteritis. Case report of 15 years old adolescent female hailing from lower socio-economic status with past history of chronic headache, no significant family history, completely immunized presented with sudden onset weakness of right upper and lower limbs, which progressed over 1day with aphasia (recovering) with deviation of angle of mouth to left side On examination left radial ,carotid artery not palpable. Her laboratory results showed an elevated C-reactive protein and erythrocyte sedimentation rate, and subsequent CT angiography demonstrated narrowing and occlusion of the major branches of her aortic arch. We report the case of a patient with Takayasu arteritis presenting with a massive cerebral ischemic infarct and review the current literature on this topic. Conclusion of takayasu arteritis is a relatively rare disease with various and sometimes devastating clinical manifestations, such as massive cerebral ischemic infarction as in our case. Currently, there are multiple diagnostic tools and treatment options available, and more under investigation. Early, appropriate diagnosis and initiation of proper therapy could avoid further progression and reduce complications of the disease.

Pleomorphic Adenoma of Palate: A Case Report.

Pleomorphic adenoma (PA) is the most common tumor of salivary glands, which is a benign neoplasm consisting of cells exhibiting the ability to differentiate to epithelial (ductal and non-ductal) cells and mesenchymal (chondroid, myxoid and osseous) cells. The parotid gland is the most common site (90%). Approximately, 8% of PA involves the minor salivary glands; the palate is the most common site (60-75%) of minor salivary gland involvement followed by lips and other sites. Palatal PA presents clinically as a painless, slow-growing mass found on the junction of the hard and soft palate which extend in posterolateral direction. The aim of the article is to present a case of palatal PA, with a focus on the differential diagnosis and various aids of diagnosis and its successful treatment by surgical excision.

Non-mycosis Peripheral T-Cell non-Hodgkin Lymphoma involving the Skin.

A 64 years old male presented with reddish lesions all over the body of 1 month duration, high grade fever with evening rise of temperature and chills. No lymphadenopathy or hepatosplenomegaly were noted. Multiple infiltrated erythematous and hyperpigmented patches and plaques were present on the face, trunk and extremities along with few oral erosions. Histopathology from skin showed features of mycosis fungoides (MF). A further workup with Immunohistochemistry was suggestive of peri pheral T-cell lymphoma, not otherwise specified diag nosis (PTCLNOS). We report a case of PTCLNOS in a man mimicking MF clinically and histopathologically.

Clinical profile of suspected and confirmed H1N1 influenza infection in patients admitted at a tertiary care teaching hospital

Introduction: This study aimed to evaluate the clinical profile and outcomes of adult patients screened and diagnosed with H1N1 influenza infection at a tertiary care hospital in India

Materials and Methods: This retrospective study was conducted on all adult patients suspected of H1N1 influenza admitted at a teaching hospital during the epidemic period of January-March 2015. Patients were screened and classified into three categories of A, B, and C based on international guidelines. Home confinement was recommended for patients in category A, and subjects in category B received treatment with Oseltamivir capsules. In addition, patients in category C received inpatient treatment with oseltamivir capsules

Results: In total, 695 patients were screened for H1N1 influenza infection during the epidemic, out of whom 380 patients [54.6%] were in category A, 264 [37.9%] were in category B, and 51 [7.3%] were in category C. Throat swabs were collected and examined for 192 [ 27.6%] patients, and 59 [ 8.4%] cases were positive for H1N1 infection

Conclusion: According to the results of this study, close vigilance over the symptoms of patients infected with H1N1 influenza is more important than treatment and screening of suspicious cases during the epidemics of this infection. This is a retrospective cross sectional study. Hence, there were no comparative controls. The limitation of this study is, thus the lack of control

Erythematous nodules of the hand: A rare site of metastatic breast carcinoma.

Acral cutaneous metastasis is a rare phenomenon. A 38-year-old woman presented with painful lesions in the left hand since 1 month. On examination, multiple painful, erythematous, lobulated plaques and nodules were present over the palmar aspect of the finger tips and thenar eminence. Biopsy of the nodule revealed lobules of small pleomorphic epithelial cells arranged in singles, small nests, cords and small abortive luminal pattern in an abundant mucoid matrix, suggestive of metastatic mucinous carcinoma. Past history revealed that the patient had undergone bilateral mastectomy for carcinoma breast. Diagnosis of cutaneous metastases is based on clinical history and histopathological examination. Identification of the primary tumor is very important for prompt treatment and prognosis. The rarity of pure acral cutaneous metastasis and its possible pathogenetic mechanisms are discussed.

Eruption times and patterns of permanent teeth in school children of India.

Aim: To study the eruption pattern of permanent teeth excluding third molars in school children of Mysore, South India. Objectives: To compare the eruption times determined with previous studies. To determine range of variation of the eruption time of each tooth and evaluate if any preponderance exists in the eruption timings of maxillary and mandibular teeth and between boys and girls. Materials and Methods: This was a descriptive cross sectional study. A random sample of 5007 school children in the age group of 5-14 years was selected. The mean age of eruption of individual permanent teeth was recorded and results were analyzed using Probit analysis. Results: The study population included 2371 boys constituting 47.26% and 2636 girls constituting 52.65% of the total sample. In the age group of 5 years, one of the permanent teeth was found to be erupted. In the age group of 14 years, all the permanent teeth except third molar had erupted. Girls showed early tooth eruption compared to boys. Mandibular teeth erupted earlier than maxillary teeth in both the sexes. Right and left sided teeth erupted at the same time in both the arches. Conclusion: The mean ages of eruption obtained from the present study are strikingly comparable with those of other investigators in different populations across the world. Since the current study involves a large sample of children, the data reported in this study could be used as standards when assessing permanent tooth eruption in Indian children.

Evaluation of acoustic shock induced early hearing loss with audiometer and distortion product otoacoustic emissions.

Background: Acoustic shock injury has been described as a permanent injury to the auditory system either due to daily noise dose of in excess of 85 decibels or very loud impulse sound reputed to be in excess of 120 decibels and acoustic incidents. This study was performed to compare the results of audiogram and the newer diagnostic method distortion product otoacoustic emissions (DPOAEs) parameters due to acoustic shock injury in call center professionals working in a noisy environment and prone to acoustic injury. Materials and Methods: Hearing functions of 340 subjects were first assessed with pure tone audiometry and then DPOAEs results were compared among acoustic shock exposed subjects with normal audiogram and those with abnormal audiogram. Results: Out of 340 acoustic shock exposed subjects 304 were normal on audiometric testing and 34 had abnormal audiograms. Subsequently on DPOAE testing out of 304 acoustic shock exposed subjects with normal audiogram 125 failed and 181 passed. Conclusions: This study showed that DPOAEs are more sensitive than audiometry to detect pre-symptomatic inner ear damage. It may play a role as screening and monitoring test for acoustic shock-exposed workers.

Herpes zoster induced alveolar necrosis in an immuocompetent patient

Herpes group of viruses give rise to vivid manifestations in the human body. Herpes zoster infection and reactivation results in characteristic vesiculo-bullous-ulcerative lesions of the face and the oral cavity. Herpes zoster induced alveolar bone necrosis is a rare manifestation and very few cases reports are available in the literature. A 60-year-old male patient presented with a complaint of an ulcer over the lower lip since a month. Based on the clinical features, a diagnosis of herpes zoster of mandibular division of right trigeminal nerve inducing alveolar necrosis with spontaneous exfoliation of teeth was proposed. Herpes zoster infection is a rather common viral infection. The manifestations of this infection can range from subtle to extensive lesions such as alveolar bone necrosis and exfoliation of teeth. When such widespread expression of the infection is noted the clinician should investigate to determine an underlying immunocompromised status

Unilateral nevoid hyperkeratosis of the nipple: a report of two cases.

Nevoid hyperkeratosis of the nipple and areola is an unusual condition. Two female patients aged 31 and 18 years presented with chronic unilateral warty lesions of the nipple. One patient had difficulty in breastfeeding from the affected side. A skin biopsy showed acanthosis, hyperkeratosis, papillomatosis and lymphocytic infiltrate in the dermis. There was no significant improvement with topical tretinoin cream in both the patients.

Severe cutaneous adverse drug reaction to leflunomide: a report of five cases.

Medications used to treat human ailments are known to cause cutaneous reactions which may vary in their severity. Leflunomide, an immunomodulating agent recently introduced to treat rheumatoid arthritis, is reported to cause severe cutaneous reactions. We are reporting five such cases. All our patients were started on leflunomide for rheumatoid arthritis, 4-6 weeks before the onset of cutaneous reaction and were admitted to the hospital with the common complaints of fever, skin rash and generalized weakness. All of them had characteristic pattern of events such as delayed onset of reaction, widespread and long lasting skin rash and internal organ involvement. These features suggest a possibility of drug hypersensitivity syndrome to leflunomide. Careful dosing and periodic monitoring of patients treated with leflunomide for possible adverse drug reaction is recommended.