ABSTRACT
ABSTRACT The intent of the current work is to study the effect of polyethylene glycol 8000 and polyethylene glycol 10000 as hydrophilic carriers on dissolution behaviour of flurbiprofen. In the present study, solvent evaporation method was used to prepare flurbiprofen solid dispersions and evaluated for physico-chemical properties, drug-carrier compatibility studies and dissolution behaviour of drug. Solubility studies showed more solubility in higher pH values and formulations SD4 and SD8 were selected to prepare the fast dissolving tablets. FTIR and DSC study showed no interaction and drug was dispersed molecularly in hydrophilic carrier. XRD studies revealed that there was change in the crystallinity of the drug. The results of In vitro studies showed SD8 formulation confer significant improvement (p<0.05) in drug release, Q20 was 99.08±1.35% compared to conventional and marketed tablets (47.31±0.74% and 56.86±1.91%). The mean dissolution time (MDT) was reduced to 8.79 min compared to conventional and marketed tablets (25.76 and 22.22 min.) indicating faster drug release. The DE (% dissolution efficiency) was increased by 2.5 folds (61.63%) compared to conventional tablets (23.71%). From the results, it is evident that polyethylene glycol solid dispersions in less carrier ratio may enhance the solubility and there by improve the dissolution rate of flurbiprofen.
Subject(s)
Solubility , Flurbiprofen/analysis , Dissolution , Tablets/classification , Pharmaceutical PreparationsABSTRACT
The present study was intended to formulate the ketoprofen emulgels using different viscosity grades of hydroxypropyl methylcellulose and carbopol as gelling agents. All the prepared emulgels were shown acceptable physical properties concerning colour, homogeneity, consistency, and pH value. Emulgels containing hydroxypropyl methylcellulose were poor in clarity when compared to carbopol formulations. The influence of the type of gelling agent on the drug release from the prepared emulgels was investigated and carbopol 934 showed good results not only in the drug release but also in physical evaluation parameters. From the drug release studies, F3 formulation showed 98.46±2.05% drug release in 8 h with good clarity and physical appearance. The T10% and T80% values of best formulation F3 was found to be 0.9 h and 6.6 h respectively. The T10% and T80% was higher for formulations with carbopol in low concentration when compared to hydroxypropyl methylcellulose K 4M and K 15M in high concentrations, indicating better controlled release. FTIR studies proved the compatibility between drug and carbopol. From the stability studies, similarity index value between dissolution profiles of F3 formulation before and after storage was found to be 87.16. Hence the development of ketoprofen emulgels is a suitable way for topical administration.
ABSTRACT
The present study enlightens to enhance the dissolution rate, absorption efficiency and bioavailability of Nimesulide, a poorly soluble-highly permeable drug by preparing liquisolid compacts. Nimesulide liquisolid tablets were prepared by using polyethylene glycol-400 as a non-volatile liquid vehicle, microcrystalline cellulose, hydroxypropyl methylcellulose-E15, starch were used as carrier materials and silica gel as coating material in different ratios. They were characterized for different physical parameters to comply with pharmacopoeial limits. In vitro dissolution profiles of the liquisolid formulations were studied and compared with conventional formulation in pH 7.4 phosphate buffer and it was found that liquisolid tablets formulated with microcrystalline cellulose showed significant higher drug release rates than conventional tablets due to increase in wetting properties. DSC study showed that there is no interaction between the drug and excipients. In conclusion, development of nimesulide liquisolid tablets is a good approach to enhance the dissolution rate.