ABSTRACT
The aim of presented study was to assess pharmacokinetic properties of fexofenadine in Taiwanese volunteers. iniv-three healthy male subjects received 180mg fexofenadine. Blood samples were drawn at appropriate times
Drug concentrations of fexofenadine were measured by a LC/MS/MS method. Non-compartmental models were applied to ribe the pharmacokinetic characters of fexofenadine. After oral administration of fexofenadine, the T[max] was :81h. The C[max] 703.76+/-298.94ng/mL and AUC[0.00] was 4582.52+/-1812.59hxng/mL. The elimination half-life of lenadine was 12.18+/-3.61h. One of the most important determinants was to prove the similar results in the pharmacokinetics of fexofenadine in Taiwan subjects compared with the reported data of other ethnic origin