Anxiolytic and Antiulcer Activity of Leaves of Andrographys Paniculata in Experimental Model.

The Petroleum ether and Chloroform extract of Andrographis paniculata leaves was investigated for its potential to protect gastric mucosa against pylorus ligation induced ulcer and to find out the anxiolytic action in elevated plus maze model. Chloroform extract at the dose of 200mg/kg protected the gastric mucosa in the pylorus ligation ulcer induction significantly (p<0.001) when compared with that of the standard drug famotidine (10mg/kg) and acts as a potent antiulcer effect. Elevated plus maze results were significant in alleviating the anxiety in the animals’ results in increased time spent and entries into the open arm compared with the standard drug diazepam (1mg/kg).

Design, Synthesis of New C(14)-Andrographolide Analogues and their Cytotoxic Activity.

A new series of andrographolide analogues were synthesized from andrographolide, the cytotoxic constituent of the plant Andrographis paniculata. The derived analogs (4a-4e) were evaluated for their cytotoxic activity against lung cancer (H522), leukemia K562, breast cancer (MCF-7/ADR) and prostate cancer (DU145) cell lines. Most of the analogues display significant cytotoxic activity against tested cell lines. The allyl derivative 4c had higher activity than parent compound andrographolide 1, and standard drug cisplatin against tested cell lines.