Apolipoprotein E Polymorphism In Two Populations Of Andhra Pradesh.

Apolipoprotein (apo) E genotypes were determined on 182 subjects of Kshatriya and 38 subjects of the Mala populations of Andhra Pradesh. Five genotypes (2/3, 2/4, 3/3, 3/4, 4/4) in the Kshatriya and three genotypes (2/3, 3/3, 3/4) in the Mala, representing three common alleles (e2, e3 and e4 allele frequencies were 0.052, 0.852 and 0.096 for the Kshatriyas and 0.040, 0.921 and 0.040 for the Malas, respectively). No significant difference was observed between these two populations for apolipoprotein (apo) E polymorphism. The genotypic distribution of apoE was at Hardy-Weinberg equilibrium in these two populations. Wide ranges of differences were observed in allele frequencies between populations of the world.