ABSTRACT
Alkaline phosphatase, ALP is found in all tissue of the body.(4) The enzyme responsible for extracellular catabolism of glutathione’s is Gamma glutamyltransferase, GGT]. It is the main thiol intracellular antioxidant agent. The larger function of enzyme is to transport amino acid and peptide into the cell across the cell membrane in the form of gamma glutamyl peptidase. The only iodine containing amine hormones in the vertebrate are Triiodothyronine (T3) and thyroxine (T4). Methods: All samples were taken from hypothyroid, hyperthyroid and euthyroid subjects who fasted for at least 8 hours before the blood collection.Serum separated and analyzed for T3, T4, TSH, CK-NAC, CK-MB, LDH and AST(SGOT) . The sample was processed in standardized manner under set protocol in the Department of Biochemistry. Results: Among the total of 300 subjects of ages 25 -50 years of both sexes were included in the study, 100 were hypothyroid, 100 were hyperthyroid and 100 were euthyroid. Their serum levels of T3, T4 and TSH were estimated and confirmed. Conclusion: The present study might be beneficial in public health and clinical practice, as both thyroid disorders and cardiovascular diseases are important issue of concern to reduce the morbidity and mortality.
ABSTRACT
Serum uric acid (SUA) is an end product of purine metabolism. SUA is excreted mainly through the kidneys. Multiple mechanisms have been reported to show the association of hyperuricemia with glucose intolerance. The association between insulin and renal resistance to absorption of urates has been found out to be the most important among these mechanisms. Methods: This comparative study contains 50 subjects of type 2 diabetes having an age group of 40-65 years were participated in case & 50 healthy subjects as control group. This case control study conducted in the department of department of biochemistry, LPS institute of Cardiology, GSVM medical college, Kanpur. Results: In the case-control study were found 54% male and 46% female in case group & 42% female and 58% female. We suggested that in study group 44% cases were belongs to 61-65 age group followed by other while in control group 42% were belongs to 61-65 age group followed by other age group. Conclusion: This study conclude that there were significant correlation between uric acid and HOMA-IR value. Hyperuricemia is related to risk factors for insulin resistance in type 2 diabetes. The study concluded a significant progressive relationship between increased uric acid level with respect to HOMA-IR levels which is an indices of insulin resistance.