ABSTRACT
The possible role of magnesium ions (Mg++) in the pathogenesis of essential hypertension has recently received increasing attention although magnesium has been neglected trace element till now despite its important role in various metabolic reactions involved in high energy transfer reactions, themogenesis, protein synthesis and anabolism because magnesium is a cofactor in various enzymes like alkaline phosphatases, ATPase, creatine kinases, pyruvate kinases and phosphogluco mutases etc. study was conducted by Department of Physiology, Department of Biochemistry and Department of Medicine, KGMC, Lucknow. Study shows that The serum magnesium variation in a particular group or much difference with previous studies could be because of difference in mineral content of water from locality to locality.