ABSTRACT
Background & objectives: There is a paucity of data regarding immunogenicity of recently introduced measles–rubella (MR) vaccine in Indian children, in which the first dose is administered below one year of age. This study was undertaken to assess the immunogenicity against rubella and measles 4-6 wk after one and two doses of MR vaccine administered under India’s Universal Immunization Programme (UIP). Methods: In this longitudinal study, 100 consecutive healthy infants (9-12 months) of either gender attending the immunization clinic of a tertiary care government hospital affiliated to a medical college of Delhi for the first dose of routine MR vaccination were enrolled. MR vaccine (0.5 ml, subcutaneous) was administered to the enrolled participants (1st dose at 9-12 months and 2nd dose at 15-24 months). On each follow up (4-6 wk post-vaccination), 2 ml of venous blood sample was collected to estimate the antibody titres against measles and rubella using quantitative ELISA kits. Seroprotection (>10 IU/ml for measles and >10 WHO U/ml for rubella) and antibody titres were evaluated after each dose. Results: The seroprotection rate against rubella was 97.5 and 100 per cent and against measles was 88.7 per cent and 100 per cent 4-6 wk after the first and second doses, respectively. The mean (standard deviation) titres against rubella and measles increased significantly (P<0.001) after the second dose in comparison to the levels after the first dose by about 100 per cent and 20 per cent, respectively. Interpretation & conclusions: MR vaccine administered below one year of age under the UIP resulted in seroprotection against rubella and measles in a large majority of children. Furthermore, its second dose resulted in seroprotection of all children. The current MR vaccination strategy of two doses, out of which the first is to be given to infants below one year of age, appears robust and justifiable among Indian children.
ABSTRACT
Introduction: Turmeric also known as Curcuma longa thatis widely used as a spice, preservative, coloring agent, and asa household remedy is coming a long way as an alternativemanagement option for periodontal conditions. Curcumin themain yellow bioactive part of turmeric has huge spectrum ofactivity such as anti-inflammatory, antioxidant, antimutagenic,anticarcinogenic, anticoagulant, antidiabetic, antifertility,antibacterial, antiprotozoal, antiviral, antivenom, antiulcer,antifibrotic, hypotensive, and hypocholesteremic activities.The present study was conducted with the aim to determinethe effect of curcumin gel along with SRP in chronic gingivitiscases.Material and methods: The present prospective studyconsisted of 30 subjects as cases and controls respectively.The study was conducted in the department of periodontics ofthe hospital. Scaling was performed by piezoelectric scaler bytrained personnel. After, thorough clearance curcumin gel waslocally applied amongst the cases. All the patients were givensame postoperative instructions and medicaments. Followup was performed after 30 days and the values of gingivalindex were noted. All the data thus obtained was arranged ina tabulated form and analysed using SPSS software. Studentt test was used for statistical analysis and probability value ofless than 0.05 was regarded as significant.Results: The present study consisted of 30 patients as casesand 30 as controls. The mean age of the subjects was 36.42+/-5.22 years. The mean value at day 0 amongst the cases and thecontrols was 2.61+/-0.54 and 2.65+/-0.66 respectively. Themean value at day 30 amongst the cases and the controls was1.90+/-0.38 and 1.45+/-0.45 respectively. On applying studentt test there was a significant improvement amongst the casescompared to the controls on Day 30.Conclusion: Application of curcumin gel could also lead to adecrease in the chances of surgical treatment after SRP as thepocket depth improves significantly
ABSTRACT
Introduction: Turmeric also known as Curcuma longa thatis widely used as a spice, preservative, coloring agent, and asa household remedy is coming a long way as an alternativemanagement option for periodontal conditions. Curcumin themain yellow bioactive part of turmeric has huge spectrum ofactivity such as anti-inflammatory, antioxidant, antimutagenic,anticarcinogenic, anticoagulant, antidiabetic, antifertility,antibacterial, antiprotozoal, antiviral, antivenom, antiulcer,antifibrotic, hypotensive, and hypocholesteremic activities.The present study was conducted with the aim to determinethe effect of curcumin gel along with SRP in chronic gingivitiscases.Material and methods: The present prospective studyconsisted of 30 subjects as cases and controls respectively.The study was conducted in the department of periodontics ofthe hospital. Scaling was performed by piezoelectric scaler bytrained personnel. After, thorough clearance curcumin gel waslocally applied amongst the cases. All the patients were givensame postoperative instructions and medicaments. Followup was performed after 30 days and the values of gingivalindex were noted. All the data thus obtained was arranged ina tabulated form and analysed using SPSS software. Studentt test was used for statistical analysis and probability value ofless than 0.05 was regarded as significant.Results: The present study consisted of 30 patients as casesand 30 as controls. The mean age of the subjects was 36.42+/-5.22 years. The mean value at day 0 amongst the cases and thecontrols was 2.61+/-0.54 and 2.65+/-0.66 respectively. Themean value at day 30 amongst the cases and the controls was1.90+/-0.38 and 1.45+/-0.45 respectively. On applying studentt test there was a significant improvement amongst the casescompared to the controls on Day 30.Conclusion: Application of curcumin gel could also lead to adecrease in the chances of surgical treatment after SRP as thepocket depth improves significantly
ABSTRACT
Introduction: Dental aesthetic plays an important role inoverall facial representation of a person. A smile enhancesexpression of a person. A perfect harmony of size, form, andposition of the teeth and their relation with alveolar boneand gingival tissue have important role in creating a pleasingsmile. Excessive gingival melanin pigmentation can givebrownish to blackish colour to gingival.Case report: This case report highlights a case ofhyperpigmentation gingiva with midline diastema which wastreated by gingival depigmentation using the scalpel techniquewith frenectomy and cosmetic filling.Conclusion: The appearance of ‘black gum’ especially inhigh smile line person gives unaesthetic smile. The demandfor cosmetic therapy is commonly in people with pigmentedgingiva.
ABSTRACT
The kinetics of alpha-chymotrypsin (alpha-CT) catalyzed hydrolysis of 4-nitrophenyl acetate has been studied in aqueous solution of alkyldimethylethanolammonium bromide (cetyl, dodecyl, decyl) surfactants at concentrations below and above their critical micelle concentration. From Michaelis-Mcnten kinetics, the catalytic rate constant kcat and the Michaelis constant KM have been determined. The bell-shaped profiles of alpha-CT activity with increasing surfactant concentrations indicate the interaction between the micelle-bound enzyme and substrate.